(Mechano)chemical modification of polyvinyl chloride with azole-based drugs

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(Mechano)chemical modification of polyvinyl chloride with azole-based drugs. / Al-Sammarraie, Eman S. A.; Al-Ithawi, Wahab A. K.; Baklykov, Artem V. и др.
в: Chimica Techno Acta, Том 11, № 2, 2024.

Результаты исследований: Вклад в журнал › Статья › Рецензирование

BibTeX

@article{c1682bc5694b4304a6ad849539c4b15b,

title = "(Mechano)chemical modification of polyvinyl chloride with azole-based drugs",

abstract = "Polyvinyl chloride (PVC) plays an important role in industry; however, due to its uncontrolled accumulation in the environment, the methods for its utilization are of high demand. Herein we wish to report an approach for the utilization of PVC via its use as a carrier for some azole-based drugs, such as 2-mercaptobenzothiazole (multi-activity drug), 4-oxo-1,4-dihydro-pyrazolo[5,1-c]-1,2,4-triazine-3,8-dicarboxylic acid diethyl ester (antidiabetic drug) and 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pyrimidinide (antiviral drug). The abovementioned approach involves the reaction between PVC and potassium or sodium salts of these azole-based drugs either in solution or under ball-milling conditions. The as-obtained PVCs modified with azole-based drugs were isolated for the first time and characterized by means of 1H NMR-spectroscopy as well as gel-permeation chromatography (GPC).",

author = "Al-Sammarraie, {Eman S. A.} and Al-Ithawi, {Wahab A. K.} and Baklykov, {Artem V.} and Platonov, {Vadim A.} and Altobee, {Aqeel M. K.} and Glebov, {Nikita S.} and Khasanov, {Albert F.} and Kovalev, {Igor S.} and Nikonov, {Igor L.} and Kopchuk, {Dmitry S.} and Sapozhnikova, {Irina M.} and Sabirova, {Tamara M.} and Yanxian Jin and Zyryanov, {Grigory V.} and Rusinov, {Vladimir L.}",

note = "The authors are grateful to the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-1118 dated 29.06.2022), http://www.minobrnauki.gov.ru. A.F.K. is thankful to Russian Science Foundation (Grant No. 19-73-10144-P) for support (synthesis and study of polymer 2). This work was performed using the equipment of the Joint Use Center \{"}Spectroscopy and Analysis of Organic Compounds\{"} of the I. Ya. Postovsky Institute of Organic Syn-thesis of the Ural Branch of the Russian Academy of Sciences.",

year = "2024",

doi = "10.15826/chimtech.2024.11.2.11",

language = "English",

volume = "11",

journal = "Chimica Techno Acta",

issn = "2409-5613",

publisher = "Издательство Уральского университета",

number = "2",

}

RIS

TY - JOUR

T1 - (Mechano)chemical modification of polyvinyl chloride with azole-based drugs

AU - Al-Sammarraie, Eman S. A.

AU - Al-Ithawi, Wahab A. K.

AU - Baklykov, Artem V.

AU - Platonov, Vadim A.

AU - Altobee, Aqeel M. K.

AU - Glebov, Nikita S.

AU - Khasanov, Albert F.

AU - Kovalev, Igor S.

AU - Nikonov, Igor L.

AU - Kopchuk, Dmitry S.

AU - Sapozhnikova, Irina M.

AU - Sabirova, Tamara M.

AU - Jin, Yanxian

AU - Zyryanov, Grigory V.

AU - Rusinov, Vladimir L.

N1 - The authors are grateful to the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-1118 dated 29.06.2022), http://www.minobrnauki.gov.ru. A.F.K. is thankful to Russian Science Foundation (Grant No. 19-73-10144-P) for support (synthesis and study of polymer 2). This work was performed using the equipment of the Joint Use Center \"Spectroscopy and Analysis of Organic Compounds\" of the I. Ya. Postovsky Institute of Organic Syn-thesis of the Ural Branch of the Russian Academy of Sciences.

PY - 2024

Y1 - 2024

N2 - Polyvinyl chloride (PVC) plays an important role in industry; however, due to its uncontrolled accumulation in the environment, the methods for its utilization are of high demand. Herein we wish to report an approach for the utilization of PVC via its use as a carrier for some azole-based drugs, such as 2-mercaptobenzothiazole (multi-activity drug), 4-oxo-1,4-dihydro-pyrazolo[5,1-c]-1,2,4-triazine-3,8-dicarboxylic acid diethyl ester (antidiabetic drug) and 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pyrimidinide (antiviral drug). The abovementioned approach involves the reaction between PVC and potassium or sodium salts of these azole-based drugs either in solution or under ball-milling conditions. The as-obtained PVCs modified with azole-based drugs were isolated for the first time and characterized by means of 1H NMR-spectroscopy as well as gel-permeation chromatography (GPC).

AB - Polyvinyl chloride (PVC) plays an important role in industry; however, due to its uncontrolled accumulation in the environment, the methods for its utilization are of high demand. Herein we wish to report an approach for the utilization of PVC via its use as a carrier for some azole-based drugs, such as 2-mercaptobenzothiazole (multi-activity drug), 4-oxo-1,4-dihydro-pyrazolo[5,1-c]-1,2,4-triazine-3,8-dicarboxylic acid diethyl ester (antidiabetic drug) and 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pyrimidinide (antiviral drug). The abovementioned approach involves the reaction between PVC and potassium or sodium salts of these azole-based drugs either in solution or under ball-milling conditions. The as-obtained PVCs modified with azole-based drugs were isolated for the first time and characterized by means of 1H NMR-spectroscopy as well as gel-permeation chromatography (GPC).

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85196277055

U2 - 10.15826/chimtech.2024.11.2.11

DO - 10.15826/chimtech.2024.11.2.11

M3 - Article

VL - 11

JO - Chimica Techno Acta

JF - Chimica Techno Acta

SN - 2409-5613

IS - 2

ER -

ID: 58848322