Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - (Mechano)chemical modification of polyvinyl chloride with azole-based drugs
AU - Al-Sammarraie, Eman S. A.
AU - Al-Ithawi, Wahab A. K.
AU - Baklykov, Artem V.
AU - Platonov, Vadim A.
AU - Altobee, Aqeel M. K.
AU - Glebov, Nikita S.
AU - Khasanov, Albert F.
AU - Kovalev, Igor S.
AU - Nikonov, Igor L.
AU - Kopchuk, Dmitry S.
AU - Sapozhnikova, Irina M.
AU - Sabirova, Tamara M.
AU - Jin, Yanxian
AU - Zyryanov, Grigory V.
AU - Rusinov, Vladimir L.
N1 - The authors are grateful to the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-1118 dated 29.06.2022), http://www.minobrnauki.gov.ru. A.F.K. is thankful to Russian Science Foundation (Grant No. 19-73-10144-P) for support (synthesis and study of polymer 2). This work was performed using the equipment of the Joint Use Center \"Spectroscopy and Analysis of Organic Compounds\" of the I. Ya. Postovsky Institute of Organic Syn-thesis of the Ural Branch of the Russian Academy of Sciences.
PY - 2024
Y1 - 2024
N2 - Polyvinyl chloride (PVC) plays an important role in industry; however, due to its uncontrolled accumulation in the environment, the methods for its utilization are of high demand. Herein we wish to report an approach for the utilization of PVC via its use as a carrier for some azole-based drugs, such as 2-mercaptobenzothiazole (multi-activity drug), 4-oxo-1,4-dihydro-pyrazolo[5,1-c]-1,2,4-triazine-3,8-dicarboxylic acid diethyl ester (antidiabetic drug) and 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pyrimidinide (antiviral drug). The abovementioned approach involves the reaction between PVC and potassium or sodium salts of these azole-based drugs either in solution or under ball-milling conditions. The as-obtained PVCs modified with azole-based drugs were isolated for the first time and characterized by means of 1H NMR-spectroscopy as well as gel-permeation chromatography (GPC).
AB - Polyvinyl chloride (PVC) plays an important role in industry; however, due to its uncontrolled accumulation in the environment, the methods for its utilization are of high demand. Herein we wish to report an approach for the utilization of PVC via its use as a carrier for some azole-based drugs, such as 2-mercaptobenzothiazole (multi-activity drug), 4-oxo-1,4-dihydro-pyrazolo[5,1-c]-1,2,4-triazine-3,8-dicarboxylic acid diethyl ester (antidiabetic drug) and 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pyrimidinide (antiviral drug). The abovementioned approach involves the reaction between PVC and potassium or sodium salts of these azole-based drugs either in solution or under ball-milling conditions. The as-obtained PVCs modified with azole-based drugs were isolated for the first time and characterized by means of 1H NMR-spectroscopy as well as gel-permeation chromatography (GPC).
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85196277055
U2 - 10.15826/chimtech.2024.11.2.11
DO - 10.15826/chimtech.2024.11.2.11
M3 - Article
VL - 11
JO - Chimica Techno Acta
JF - Chimica Techno Acta
SN - 2409-5613
IS - 2
ER -
ID: 58848322