TY - JOUR

T1 - Evaluation of photon, proton, and alpha interaction parameters of EDTMPLu and MDPLu medications used for some bone cancer

AU - Mostafa, A.

AU - Uosif, M.

AU - Issa, Shams

AU - Zhukovsky, M.

AU - Alrowaili, Z.

AU - Zakaly, Hesham

N1 - The authors extend their appreciation to the Deanship of Scientific Research at Jouf University for funding this work through research group no ( DSR2022-RG-0124 ).

PY - 2024/3/1

Y1 - 2024/3/1

N2 - In this study, we explore the interactions of photons, protons, and alpha with matter in the context of two drugs, MDPLu and EDTMPLu, delving into the interesting field of radiation shielding. Our research is focused on the mass attenuation coefficient (GMAC), effective atomic number (Zeff), buildup factors (EBF and EABF), and dosimetry parameters with the goal of understanding how these factors affect how well these drugs work as radiation shields. Our results show that the effective atomic number was higher in substances with a higher percentage of Z element component, and that the GMAC values for MDPLu medications were the highest, while the GMAC values for EDTMPLu medications were the lowest. Additionally, MDPLu showed the lowest exposure buildup factor (EBF) and energy absorption buildup factor (EABF), further validating its efficacy as a shielding material. Moreover, MDPLu displayed a higher mass-stopping power (MSP) for proton interactions in the lower energy range, making it a prime candidate for specific radiation shielding applications. These insights contribute to our understanding of the radiation-shielding efficacy of bone cancer treatment medications.

AB - In this study, we explore the interactions of photons, protons, and alpha with matter in the context of two drugs, MDPLu and EDTMPLu, delving into the interesting field of radiation shielding. Our research is focused on the mass attenuation coefficient (GMAC), effective atomic number (Zeff), buildup factors (EBF and EABF), and dosimetry parameters with the goal of understanding how these factors affect how well these drugs work as radiation shields. Our results show that the effective atomic number was higher in substances with a higher percentage of Z element component, and that the GMAC values for MDPLu medications were the highest, while the GMAC values for EDTMPLu medications were the lowest. Additionally, MDPLu showed the lowest exposure buildup factor (EBF) and energy absorption buildup factor (EABF), further validating its efficacy as a shielding material. Moreover, MDPLu displayed a higher mass-stopping power (MSP) for proton interactions in the lower energy range, making it a prime candidate for specific radiation shielding applications. These insights contribute to our understanding of the radiation-shielding efficacy of bone cancer treatment medications.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85177840378

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001132565400001

U2 - 10.1016/j.radphyschem.2023.111419

DO - 10.1016/j.radphyschem.2023.111419

M3 - Article

VL - 216

JO - Radiation Physics and Chemistry

JF - Radiation Physics and Chemistry

SN - 0969-806X

M1 - 111419

ER -