In this study, we explore the interactions of photons, protons, and alpha with matter in the context of two drugs, MDPLu and EDTMPLu, delving into the interesting field of radiation shielding. Our research is focused on the mass attenuation coefficient (GMAC), effective atomic number (Zeff), buildup factors (EBF and EABF), and dosimetry parameters with the goal of understanding how these factors affect how well these drugs work as radiation shields. Our results show that the effective atomic number was higher in substances with a higher percentage of Z element component, and that the GMAC values for MDPLu medications were the highest, while the GMAC values for EDTMPLu medications were the lowest. Additionally, MDPLu showed the lowest exposure buildup factor (EBF) and energy absorption buildup factor (EABF), further validating its efficacy as a shielding material. Moreover, MDPLu displayed a higher mass-stopping power (MSP) for proton interactions in the lower energy range, making it a prime candidate for specific radiation shielding applications. These insights contribute to our understanding of the radiation-shielding efficacy of bone cancer treatment medications.