Using the Drosophila melanogaster model object, the presence of protective properties in 10% of Prunella grandiflora L. (Lamiaceae) extract was determined in relation to the toxic and cytotoxic effects of the antitumor drug etoposide in two concentrations of 800 and 8000 μg/kg of nutrient medium. The grass P. grandiflora was collected in the flowering phase in Sverdlovsk region (N 56°09'22.0'', E 058°32'19.6'') in 2021. No genotoxic manifestations of the extract were found. Comparative characteristics of wing parameters under the influence of etoposide at a dose of 800 and 8000 g showed significant differences in linear and two-dimensional parameters of the wing.