TY - JOUR

T1 - Solfeggio-frequency music exposure reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish

AU - dos Santos, Amanda C.

AU - Abreu, Murilo S.

AU - de Mello, Gabriel P.

AU - Costella, Vanusa

AU - do Amaral, Nicoli R.

AU - Zanella, Alexander

AU - Poletto, Júlia

AU - Petersen, Elena V.

AU - Kalueff, Allan V.

AU - Giacomini, Ana C. V. V.

N1 - ACVVG is supported by the Research Support Foundation of the State of Rio Grande do Sul (FAPERGS) research fellowships 19/2551-0001-669-7. ACS is supported by the Coordination of Improvement of Higher Education Personnel (CAPES-PROSUC I) scholarship. The authors thank Manuela G. Bernardon, Sirlei Cazarotto, and Vítor H. B. Dal Magro (University of Passo Fundo, Brazil) for their assistance with experimental procedures. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. AVK was supported by the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program).

PY - 2023/7/26

Y1 - 2023/7/26

N2 - Music therapy has long been used as a non-pharmacological intervention to improve cognitive function and mood in humans. Mounting rodent evidence also supports beneficial impact of music exposure on animal cognitive performance. The zebrafish (Danio rerio) is an important emerging aquatic animal model in translational biomedical and neuroscience research. Here, we evaluate the effects of intermittent (2-h or 6-h twice daily) and continuous (24-h) solfeggio-frequency music exposure on behavioral, cognitive and endocrine parameters in adult zebrafish whose circadian rhythm was disturbed by a 24-h light exposure. Overall, a 24-h light exposure stress evokes overt cognitive deficits in the inhibitory avoidance test and elevates zebrafish whole-body cortisol levels. However, these effects were reversed by solfeggio-frequency music exposure for 2 or 6 h twice daily, and by continuous 24-h exposure. Collectively, these findings suggest a positive modulation of cognitive and endocrine responses in adult zebrafish by environmental enrichment via the long-term exposure to music, and reinforces zebrafish as a robust, sensitive model organism for neurocognitive and neuroendocrine research.

AB - Music therapy has long been used as a non-pharmacological intervention to improve cognitive function and mood in humans. Mounting rodent evidence also supports beneficial impact of music exposure on animal cognitive performance. The zebrafish (Danio rerio) is an important emerging aquatic animal model in translational biomedical and neuroscience research. Here, we evaluate the effects of intermittent (2-h or 6-h twice daily) and continuous (24-h) solfeggio-frequency music exposure on behavioral, cognitive and endocrine parameters in adult zebrafish whose circadian rhythm was disturbed by a 24-h light exposure. Overall, a 24-h light exposure stress evokes overt cognitive deficits in the inhibitory avoidance test and elevates zebrafish whole-body cortisol levels. However, these effects were reversed by solfeggio-frequency music exposure for 2 or 6 h twice daily, and by continuous 24-h exposure. Collectively, these findings suggest a positive modulation of cognitive and endocrine responses in adult zebrafish by environmental enrichment via the long-term exposure to music, and reinforces zebrafish as a robust, sensitive model organism for neurocognitive and neuroendocrine research.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85159170429

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001001361200001

U2 - 10.1016/j.bbr.2023.114461

DO - 10.1016/j.bbr.2023.114461

M3 - Article

C2 - 37119977

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 450

M1 - 114461

ER -