TY - JOUR

T1 - Peculiarities of Fear Memory Extinction in Male and Female Disc1-Q31L Mice

AU - Chizhova, N. D.

AU - Smirnova, K. V.

AU - Dubrovina, N. I.

AU - Kalueff, A. V.

AU - Amstislavskaya, T. G.

N1 - This work was supported by budgetary funding for basic scientific research at the Scientific Research Institute of Neurosciences and Medicine (No. 122042700001-9). No additional grants for this research project were obtained.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - Depressive disorders are common psychopathologies highly comorbid with other mental diseases, especially post-traumatic stress disorder, with overt gender differences in susceptibility. The Disc1-Q31L mutant mice are characterized by depression-like behavior and disrupted molecular pathways involved in fear memory. Here, we assess the sex- and strain differences in learning and extinction of a conditioned passive avoidance response (CPAR) in male and female Disc1-Q31L mice vs. control C57BL/6 mice. Overall, male and female mice of both strains learned equally well but differed in fear memory extinction, i.e. the ability to form a new safety memory trace in the dark compartment of the test apparatus, previously associated with aversion. C57BL/6 female mice revealed poorer CPAR extinction than males, while both sexes showed strain differences in the extinction dynamics. While Disc1-Q31L male mice reached total extinction later than C57BL/6 males, Disc1-Q31L females exhibited no extinction throughout all 24 testing days. Collectively, this not only supports the role of Disc1 in fear memory extinction but also shows sex-dependent impact of its Q31L mutation in this process.

AB - Depressive disorders are common psychopathologies highly comorbid with other mental diseases, especially post-traumatic stress disorder, with overt gender differences in susceptibility. The Disc1-Q31L mutant mice are characterized by depression-like behavior and disrupted molecular pathways involved in fear memory. Here, we assess the sex- and strain differences in learning and extinction of a conditioned passive avoidance response (CPAR) in male and female Disc1-Q31L mice vs. control C57BL/6 mice. Overall, male and female mice of both strains learned equally well but differed in fear memory extinction, i.e. the ability to form a new safety memory trace in the dark compartment of the test apparatus, previously associated with aversion. C57BL/6 female mice revealed poorer CPAR extinction than males, while both sexes showed strain differences in the extinction dynamics. While Disc1-Q31L male mice reached total extinction later than C57BL/6 males, Disc1-Q31L females exhibited no extinction throughout all 24 testing days. Collectively, this not only supports the role of Disc1 in fear memory extinction but also shows sex-dependent impact of its Q31L mutation in this process.

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001137643100034

UR - https://elibrary.ru/item.asp?id=65051958

U2 - 10.1134/S0022093023060340

DO - 10.1134/S0022093023060340

M3 - Article

VL - 59

SP - 2338

EP - 2345

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 6

ER -