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Результаты исследований: Вклад в журнал › Статья › Рецензирование
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TY - JOUR
T1 - On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles
AU - Minigaliyeva, Ilzira A.
AU - Klinova, Svetlana
AU - Sutunkova, Marina P.
AU - Ryabova, Yuliya V.
AU - Valamina, Irene E.
AU - Shelomentsev, Ivan G.
AU - Shtin, Tatiana N.
AU - Bushueva, Tatiana
AU - Protsenko, Yuri L.
AU - Balakin, Alexander A.
AU - Lisin, Ruslan V.
AU - Kuznetsov, Daniil
AU - Katsnelson, Boris
AU - Toropova, Liubov
N1 - Open Access funding enabled and organized by Projekt DEAL. The analysis was supported by the Ministry of Science and Higher Education of the Russian Federation within the “Priority – 2030” Development Program of the Ural Federal University; the experimental data were provided by Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers.
PY - 2024
Y1 - 2024
N2 - Lead compounds are one of the most common pollutants of the workplace air and the environment. In the occupational setting, the sources of their emission, including in nanoscale form, are various technological processes associated with lead smelting and handling of non-ferrous metals and their alloys, the production of copper and batteries. Both lead poisoning and lead exposure without obvious signs of poisoning have a detrimental effect on the cardiovascular system. The purpose of this research was to investigate the mechanisms of the cardiotoxic effect of lead oxide nanoparticles (PbO NPs). The toxicological experiment involved male albino rats subchronically exposed to PbO NPs (49.6 +/- 16.0 nm in size) instilled intraperitoneally in a suspension. We then assessed post-exposure hematological and biochemical parameters of blood and urine, histological and ultrastructural changes in cardiomyocytes, and non-invasively recorded electrocardiograms and blood pressure parameters in the rodents. Myocardial contractility was studied on isolated preparations of cardiac muscles. We established that PbO NPs induced oxidative stress and damage to the ultrastructure of cardiomyocytes, and decreased efficiency of the contractile function of the myocardium and blood pressure parameters. We also revealed such specific changes in the organism of the exposed rats as anemia, hypoxia, and hypocalcemia.
AB - Lead compounds are one of the most common pollutants of the workplace air and the environment. In the occupational setting, the sources of their emission, including in nanoscale form, are various technological processes associated with lead smelting and handling of non-ferrous metals and their alloys, the production of copper and batteries. Both lead poisoning and lead exposure without obvious signs of poisoning have a detrimental effect on the cardiovascular system. The purpose of this research was to investigate the mechanisms of the cardiotoxic effect of lead oxide nanoparticles (PbO NPs). The toxicological experiment involved male albino rats subchronically exposed to PbO NPs (49.6 +/- 16.0 nm in size) instilled intraperitoneally in a suspension. We then assessed post-exposure hematological and biochemical parameters of blood and urine, histological and ultrastructural changes in cardiomyocytes, and non-invasively recorded electrocardiograms and blood pressure parameters in the rodents. Myocardial contractility was studied on isolated preparations of cardiac muscles. We established that PbO NPs induced oxidative stress and damage to the ultrastructure of cardiomyocytes, and decreased efficiency of the contractile function of the myocardium and blood pressure parameters. We also revealed such specific changes in the organism of the exposed rats as anemia, hypoxia, and hypocalcemia.
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001126380300003
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85180207971
U2 - 10.1007/s12012-023-09814-5
DO - 10.1007/s12012-023-09814-5
M3 - Article
VL - 24
SP - 49
EP - 61
JO - Cardiovascular Toxicology
JF - Cardiovascular Toxicology
SN - 1530-7905
IS - 1 (SI)
ER -
ID: 52351840