Результаты исследований: Глава в книге, отчете, сборнике статей › Глава › Рецензирование
Результаты исследований: Глава в книге, отчете, сборнике статей › Глава › Рецензирование
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TY - CHAP
T1 - Nociception-related behavioral phenotypes in adult zebrafish
AU - Costa, Fabiano V.
AU - Rosa, Luiz V.
AU - Kalueff, Allan V.
AU - Rosemberg, Denis B.
PY - 2022
Y1 - 2022
N2 - Animal models of nociception are critical for understanding biological processes associated with pain and its central effects on behavior, cognition, and emotions. However, unlike humans, laboratory animal models have less complex neural processing networks, making it difficult to correlate nociception with individual subjective experience. Although rodents are widely used in translational pain research, alternative experimental models may also be useful, reflecting evolutionarily conserved mechanisms of nociception and their related behavioral phenotypes. Novel model organisms, such as zebrafish (Danio rerio), are emerging as a promising in vivo tool to study nociception. Here, we discuss adult zebrafish models of pain and pain-like behavioral responses, summarize the existing challenges and outline future directions of research in this rapidly developing field.
AB - Animal models of nociception are critical for understanding biological processes associated with pain and its central effects on behavior, cognition, and emotions. However, unlike humans, laboratory animal models have less complex neural processing networks, making it difficult to correlate nociception with individual subjective experience. Although rodents are widely used in translational pain research, alternative experimental models may also be useful, reflecting evolutionarily conserved mechanisms of nociception and their related behavioral phenotypes. Novel model organisms, such as zebrafish (Danio rerio), are emerging as a promising in vivo tool to study nociception. Here, we discuss adult zebrafish models of pain and pain-like behavioral responses, summarize the existing challenges and outline future directions of research in this rapidly developing field.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85165274130
U2 - 10.1016/B978-0-12-820589-1.00034-8
DO - 10.1016/B978-0-12-820589-1.00034-8
M3 - Chapter
SN - 9780128205891
SN - 978-012821066-6
SN - 978-012820608-9
SP - 387
EP - 393
BT - The Neurobiology, Physiology, and Psychology of Pain
PB - Elsevier BV
ER -
ID: 54315172