TY - JOUR

T1 - Molecular Genetic Mechanisms of Circadian Rhythm Regulation and Their Role in Psychopathology

AU - Smirnova, K.

AU - Chizhova, N.

AU - Gerasimova, E.

AU - Kalueff, A. v.

AU - Amstislavskaya, T.

N1 - This work is state budget funded (theme No. 122042700001-9).

PY - 2023/11/1

Y1 - 2023/11/1

N2 - Circadian rhythms are cyclic oscillations in the intensity of biological processes associated with the change of day and night, to which many organisms have adapted during evolution. Disturbances in circadian rhythms are caused by both environmental factors (e.g., changes in the time zone or length of day/night) and disrupted internal regulation of cycles (e.g., mutations of key clock genes). These changes can trigger pathogenesis of various diseases, including psychopathologies. Since the mechanisms underlying circadian regulation are rather evolutionarily conserved, experimental in vivo animal models are actively used to probe these processes and their relationship with psychopathologies. Here, we discuss the circadian rhythm regulation, as well as their cross-taxon similarities and differences between mammals and teleost fish (zebrafish, Danio rerio). We also discuss recent findings on molecular genetic mechanisms underlying the regulation of circadian rhythms and their link to the pathogenesis of mental disorders in humans and model organisms.

AB - Circadian rhythms are cyclic oscillations in the intensity of biological processes associated with the change of day and night, to which many organisms have adapted during evolution. Disturbances in circadian rhythms are caused by both environmental factors (e.g., changes in the time zone or length of day/night) and disrupted internal regulation of cycles (e.g., mutations of key clock genes). These changes can trigger pathogenesis of various diseases, including psychopathologies. Since the mechanisms underlying circadian regulation are rather evolutionarily conserved, experimental in vivo animal models are actively used to probe these processes and their relationship with psychopathologies. Here, we discuss the circadian rhythm regulation, as well as their cross-taxon similarities and differences between mammals and teleost fish (zebrafish, Danio rerio). We also discuss recent findings on molecular genetic mechanisms underlying the regulation of circadian rhythms and their link to the pathogenesis of mental disorders in humans and model organisms.

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001137643100012

UR - https://elibrary.ru/item.asp?id=64639511

U2 - 10.1134/S0022093023060121

DO - 10.1134/S0022093023060121

M3 - Review article

VL - 59

SP - 2033

EP - 2054

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 6

ER -