TY - JOUR

T1 - Measurement of Mass Transfer Intensity in Gas–Liquid Medium of Bioreactor Circuit Using the Thermometry Method

AU - Starodumov, Ilya

AU - Nizovtseva, Irina

AU - Lezhnin, Sergey

AU - Vikharev, Sergey

AU - Svitich, Vladislav

AU - Mikushin, Pavel

AU - Alexandrov, Dmitri

AU - Kuznetsov, Nikolay

AU - Chernushkin, Dmitri

N1 - The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged.

PY - 2022

Y1 - 2022

N2 - The development of energy-efficient solutions for large-scale fermenters demands a deep and comprehensive understanding of hydrodynamic and heat and mass transfer processes. Despite a wide variety of research dedicated to measurements of mass transfer intensity in bubble flows, this research subject faces new challenges due to the topical development of new innovative bioreactor designs. In order to understand the fluid dynamics of the gas–liquid medium, researchers need to develop verified CFD models describing flows in the bioreactor loop using a progressive physical and mathematical apparatus. In the current paper, we represent the results of evaluating the key performance indicator of the bioreactor, namely the volumetric mass transfer coefficient ((Formula presented.)) known as a parameter of dominant importance for the design, operation, scale-up, and optimization of bioreactors, using the developed thermometry method. The thermometry method under consideration was examined within a series of experiments, and a comparative analysis was provided for a number of various regimes also being matched with the classical approaches. The methodology, experiment results, and data verification are given, which allow the evaluation of the effectiveness and prediction of the fluid flows dynamics in bioreactors circuits and ultimately the operational capabilities of the fermenter line. © 2022 by the authors.

AB - The development of energy-efficient solutions for large-scale fermenters demands a deep and comprehensive understanding of hydrodynamic and heat and mass transfer processes. Despite a wide variety of research dedicated to measurements of mass transfer intensity in bubble flows, this research subject faces new challenges due to the topical development of new innovative bioreactor designs. In order to understand the fluid dynamics of the gas–liquid medium, researchers need to develop verified CFD models describing flows in the bioreactor loop using a progressive physical and mathematical apparatus. In the current paper, we represent the results of evaluating the key performance indicator of the bioreactor, namely the volumetric mass transfer coefficient ((Formula presented.)) known as a parameter of dominant importance for the design, operation, scale-up, and optimization of bioreactors, using the developed thermometry method. The thermometry method under consideration was examined within a series of experiments, and a comparative analysis was provided for a number of various regimes also being matched with the classical approaches. The methodology, experiment results, and data verification are given, which allow the evaluation of the effectiveness and prediction of the fluid flows dynamics in bioreactors circuits and ultimately the operational capabilities of the fermenter line. © 2022 by the authors.

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U2 - 10.3390/fluids7120366

DO - 10.3390/fluids7120366

M3 - Article

VL - 7

JO - Fluids

JF - Fluids

SN - 2311-5521

IS - 12

M1 - 366

ER -