Standard

Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies. / Kulkarni, B.; Manjunatha, K.; Joy, Muthipeedika и др.
в: Molecular Diversity, Том 27, № 4, 2023, стр. 1867-1878.

Результаты исследований: Вклад в журнал › Статья › Рецензирование

Harvard

Kulkarni, B, Manjunatha, K, Joy, M, Sajith, A, Santra, S, Zyryanov, G, Prashantha, C, Alshammari, M & Sunil, K 2023, 'Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies', Molecular Diversity, Том. 27, № 4, стр. 1867-1878. https://doi.org/10.1007/s11030-022-10536-z

APA

Kulkarni, B., Manjunatha, K., Joy, M., Sajith, A., Santra, S., Zyryanov, G., Prashantha, C., Alshammari, M., & Sunil, K. (2023). Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies. Molecular Diversity, 27(4), 1867-1878. https://doi.org/10.1007/s11030-022-10536-z

Vancouver

Kulkarni B, Manjunatha K, Joy M, Sajith A, Santra S, Zyryanov G и др. Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies. Molecular Diversity. 2023;27(4):1867-1878. doi: 10.1007/s11030-022-10536-z

Author

Kulkarni, B. ; Manjunatha, K. ; Joy, Muthipeedika и др. / Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies. в: Molecular Diversity. 2023 ; Том 27, № 4. стр. 1867-1878.

BibTeX

@article{33b493b571f2411f91feeecaba077dc7,
title = "Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies",
abstract = "We herein report the facile synthesis of a series of 3,5-substituted-1,2,4-oxadiazole derivatives 9a–e and 10a–e in good to excellent yields by employing NMI-MsCl mediated amide bond formation reaction. The anti-inflammatory potential of the newly synthesized compounds were evaluated by anti-denaturation assay using diclofenac sodium as the reference drug. The compounds 9a and 9d demonstrated promising activity profile when compared to the reference standard. The SAR and molecular docking studies were also carried out for obtaining more details about the profound activity profile of the synthesized molecules. The synthesized compounds were docked against two target proteins TGF-β and IL-1 by AutoDock vina and Auto Dock 4.2. Graphical abstract: [Figure not available: see fulltext.]. {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.",
author = "B. Kulkarni and K. Manjunatha and Muthipeedika Joy and Ayyiliath Sajith and Sougata Santra and Grigory Zyryanov and C. Prashantha and Mohammed Alshammari and K. Sunil",
note = "The authors are thankful to Bharathiar University, Coimbatore, and Nagarjuna College of Engineering & Technology, Bengaluru, for providing all the facilities to carry out the research work. The authors are also thankful to Indian Institute of Science, Bengaluru, for providing the analytical data and spectra. Grigory V. Zyryanov is thankful to Ministry of Science and Higher Education of the Russian Federation (Grant # 075-15-2020-777) for the financial support. Sougata Santra is thankful to Russian Science Foundation (Grant # 20-73-10205) and Grants Council of the President of the Russian Federation (# NSh-1223.2022.1.3). Muthipeedika Nibin Joy is thankful to Russian Science Foundation (Grants ## 22-23-20189 and 21-13-00304). The detailed experimental procedure and characterization data including spectra are available in the Supporting Information uploaded along with the manuscript. Текст о финансировании #2 The authors are thankful to Bharathiar University, Coimbatore, and Nagarjuna College of Engineering & Technology, Bengaluru, for providing all the facilities to carry out the research work. The authors are also thankful to Indian Institute of Science, Bengaluru, for providing the analytical data and spectra. Grigory V. Zyryanov is thankful to Ministry of Science and Higher Education of the Russian Federation (Grant # 075-15-2020-777) for the financial support. Sougata Santra is thankful to Russian Science Foundation (Grant # 20-73-10205) and Grants Council of the President of the Russian Federation (# NSh-1223.2022.1.3). Muthipeedika Nibin Joy is thankful to Russian Science Foundation (Grants ## 22-23-20189 and 21-13-00304). The detailed experimental procedure and characterization data including spectra are available in the Supporting Information uploaded along with the manuscript.",
year = "2023",
doi = "10.1007/s11030-022-10536-z",
language = "English",
volume = "27",
pages = "1867--1878",
journal = "Molecular Diversity",
issn = "1381-1991",
publisher = "Kluwer Academic Publishers",
number = "4",

}

RIS

TY - JOUR

T1 - Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies

AU - Kulkarni, B.

AU - Manjunatha, K.

AU - Joy, Muthipeedika

AU - Sajith, Ayyiliath

AU - Santra, Sougata

AU - Zyryanov, Grigory

AU - Prashantha, C.

AU - Alshammari, Mohammed

AU - Sunil, K.

N1 - The authors are thankful to Bharathiar University, Coimbatore, and Nagarjuna College of Engineering & Technology, Bengaluru, for providing all the facilities to carry out the research work. The authors are also thankful to Indian Institute of Science, Bengaluru, for providing the analytical data and spectra. Grigory V. Zyryanov is thankful to Ministry of Science and Higher Education of the Russian Federation (Grant # 075-15-2020-777) for the financial support. Sougata Santra is thankful to Russian Science Foundation (Grant # 20-73-10205) and Grants Council of the President of the Russian Federation (# NSh-1223.2022.1.3). Muthipeedika Nibin Joy is thankful to Russian Science Foundation (Grants ## 22-23-20189 and 21-13-00304). The detailed experimental procedure and characterization data including spectra are available in the Supporting Information uploaded along with the manuscript. Текст о финансировании #2 The authors are thankful to Bharathiar University, Coimbatore, and Nagarjuna College of Engineering & Technology, Bengaluru, for providing all the facilities to carry out the research work. The authors are also thankful to Indian Institute of Science, Bengaluru, for providing the analytical data and spectra. Grigory V. Zyryanov is thankful to Ministry of Science and Higher Education of the Russian Federation (Grant # 075-15-2020-777) for the financial support. Sougata Santra is thankful to Russian Science Foundation (Grant # 20-73-10205) and Grants Council of the President of the Russian Federation (# NSh-1223.2022.1.3). Muthipeedika Nibin Joy is thankful to Russian Science Foundation (Grants ## 22-23-20189 and 21-13-00304). The detailed experimental procedure and characterization data including spectra are available in the Supporting Information uploaded along with the manuscript.

PY - 2023

Y1 - 2023

N2 - We herein report the facile synthesis of a series of 3,5-substituted-1,2,4-oxadiazole derivatives 9a–e and 10a–e in good to excellent yields by employing NMI-MsCl mediated amide bond formation reaction. The anti-inflammatory potential of the newly synthesized compounds were evaluated by anti-denaturation assay using diclofenac sodium as the reference drug. The compounds 9a and 9d demonstrated promising activity profile when compared to the reference standard. The SAR and molecular docking studies were also carried out for obtaining more details about the profound activity profile of the synthesized molecules. The synthesized compounds were docked against two target proteins TGF-β and IL-1 by AutoDock vina and Auto Dock 4.2. Graphical abstract: [Figure not available: see fulltext.]. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

AB - We herein report the facile synthesis of a series of 3,5-substituted-1,2,4-oxadiazole derivatives 9a–e and 10a–e in good to excellent yields by employing NMI-MsCl mediated amide bond formation reaction. The anti-inflammatory potential of the newly synthesized compounds were evaluated by anti-denaturation assay using diclofenac sodium as the reference drug. The compounds 9a and 9d demonstrated promising activity profile when compared to the reference standard. The SAR and molecular docking studies were also carried out for obtaining more details about the profound activity profile of the synthesized molecules. The synthesized compounds were docked against two target proteins TGF-β and IL-1 by AutoDock vina and Auto Dock 4.2. Graphical abstract: [Figure not available: see fulltext.]. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85139656499

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000865913600002

U2 - 10.1007/s11030-022-10536-z

DO - 10.1007/s11030-022-10536-z

M3 - Article

VL - 27

SP - 1867

EP - 1878

JO - Molecular Diversity

JF - Molecular Diversity

SN - 1381-1991

IS - 4

ER -

ID: 43608291