Development of A. solani ?-Tubulin models and comparison of docking results for benzo[d]azoles derivatives as potential antifungal agents

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Development of A. solani ?-Tubulin models and comparison of docking results for benzo[d]azoles derivatives as potential antifungal agents. / Obydennov, Konstantin L.; Kalinina, Tatiana A.; Glukhareva, Tatiana V. и др.
в: Chimica Techno Acta, Том 11, № 1, 202411104, 2024.

Результаты исследований: Вклад в журнал › Статья › Рецензирование

BibTeX

@article{2aae7be758ad4bc683a8a1d56381d0f4,

title = "Development of A. solani ?-Tubulin models and comparison of docking results for benzo[d]azoles derivatives as potential antifungal agents",

abstract = "An approach to developing a docking protocol using free software such as KNIME, DataWarrior, AutoDock Vina, AutoDockTools, OpenBabel and the SWISS-MODEL service was described. In particular, the process of gener-Ating possible isomeric structures using KNIME chemoinformatics librar-ies is described. A library of benzo[d]azoles containing 145 compounds with homologous models of Alternaria solani ?-Tubulin obtained in two ways: using the commercial Prime program and the free SWISS-MODEL service, the comparison of results was shown. Despite the less preorgani-zation of the binding cavity of the homologous model obtained using SWISS-MODEL, the correlation of the results between the two methods were observed. The correlation coefficients were as follows: Pearson was 0.65, Spearman was 0.62. According to the docking results, 99% of the studied 2-Aminobenzo[d]azoles derivatives showed a docking score of no more than 7, which indicates that these compounds are promising for studying the fungicidal activity, in particular against A. solani. Without taking into account pharmacokinetic characteristics, benzo[d]imidazole derivatives containing a sulfanilamidine substituent at the 2-Amino group and thioacetyl derivatives of 2-Aminobenzo[d]imidazole are of particular interest in the search for new antitubulin fungicides.",

author = "Obydennov, {Konstantin L.} and Kalinina, {Tatiana A.} and Glukhareva, {Tatiana V.} and Bakulev, {Vasiliy A.}",

year = "2024",

doi = "10.15826/chimtech.2024.11.1.04",

language = "English",

volume = "11",

journal = "Chimica Techno Acta",

issn = "2409-5613",

publisher = "Издательство Уральского университета",

number = "1",

}

RIS

TY - JOUR

T1 - Development of A. solani ?-Tubulin models and comparison of docking results for benzo[d]azoles derivatives as potential antifungal agents

AU - Obydennov, Konstantin L.

AU - Kalinina, Tatiana A.

AU - Glukhareva, Tatiana V.

AU - Bakulev, Vasiliy A.

PY - 2024

Y1 - 2024

N2 - An approach to developing a docking protocol using free software such as KNIME, DataWarrior, AutoDock Vina, AutoDockTools, OpenBabel and the SWISS-MODEL service was described. In particular, the process of gener-Ating possible isomeric structures using KNIME chemoinformatics librar-ies is described. A library of benzo[d]azoles containing 145 compounds with homologous models of Alternaria solani ?-Tubulin obtained in two ways: using the commercial Prime program and the free SWISS-MODEL service, the comparison of results was shown. Despite the less preorgani-zation of the binding cavity of the homologous model obtained using SWISS-MODEL, the correlation of the results between the two methods were observed. The correlation coefficients were as follows: Pearson was 0.65, Spearman was 0.62. According to the docking results, 99% of the studied 2-Aminobenzo[d]azoles derivatives showed a docking score of no more than 7, which indicates that these compounds are promising for studying the fungicidal activity, in particular against A. solani. Without taking into account pharmacokinetic characteristics, benzo[d]imidazole derivatives containing a sulfanilamidine substituent at the 2-Amino group and thioacetyl derivatives of 2-Aminobenzo[d]imidazole are of particular interest in the search for new antitubulin fungicides.

AB - An approach to developing a docking protocol using free software such as KNIME, DataWarrior, AutoDock Vina, AutoDockTools, OpenBabel and the SWISS-MODEL service was described. In particular, the process of gener-Ating possible isomeric structures using KNIME chemoinformatics librar-ies is described. A library of benzo[d]azoles containing 145 compounds with homologous models of Alternaria solani ?-Tubulin obtained in two ways: using the commercial Prime program and the free SWISS-MODEL service, the comparison of results was shown. Despite the less preorgani-zation of the binding cavity of the homologous model obtained using SWISS-MODEL, the correlation of the results between the two methods were observed. The correlation coefficients were as follows: Pearson was 0.65, Spearman was 0.62. According to the docking results, 99% of the studied 2-Aminobenzo[d]azoles derivatives showed a docking score of no more than 7, which indicates that these compounds are promising for studying the fungicidal activity, in particular against A. solani. Without taking into account pharmacokinetic characteristics, benzo[d]imidazole derivatives containing a sulfanilamidine substituent at the 2-Amino group and thioacetyl derivatives of 2-Aminobenzo[d]imidazole are of particular interest in the search for new antitubulin fungicides.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85189555761

UR - https://www.elibrary.ru/item.asp?id=65118503

U2 - 10.15826/chimtech.2024.11.1.04

DO - 10.15826/chimtech.2024.11.1.04

M3 - Article

VL - 11

JO - Chimica Techno Acta

JF - Chimica Techno Acta

SN - 2409-5613

IS - 1

M1 - 202411104

ER -

ID: 55357430