Результаты исследований: Вклад в журнал › Статья › Рецензирование
Результаты исследований: Вклад в журнал › Статья › Рецензирование
}
TY - JOUR
T1 - Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles
AU - Minigalieva, Ilzira A.
AU - Ryabova, Yuliya V.
AU - Shelomencev, Ivan G.
AU - Amromin, Lev A.
AU - Minigalieva, Regina F.
AU - Sutunkova, Yuliya M.
AU - Privalova, Larisa I.
AU - Sutunkova, Marina P.
N1 - The analysis was supported by the Ministry of Science and Higher Education of the Russian Federation within the “Priority—2030” Development Program of the Ural Federal University; the experimental data were provided by Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers.
PY - 2023
Y1 - 2023
N2 - Particulate matter, including iron nanoparticles, is one of the constituents of ambient air pollution. We assessed the effect of iron oxide (Fe2O3) nanoparticles on the structure and function of the brain of rats. Electron microscopy showed Fe2O3 nanoparticles in the tissues of olfactory bulbs but not in the basal ganglia of the brain after their subchronic intranasal administration. We observed an increase in the number of axons with damaged myelin sheaths and in the proportion of pathologically altered mitochondria in the brains of the exposed animals against the background of almost stable blood parameters. We conclude that the central nervous system can be a target for toxicity of low-dose exposure to Fe2O3 nanoparticles. © 2023 by the authors.
AB - Particulate matter, including iron nanoparticles, is one of the constituents of ambient air pollution. We assessed the effect of iron oxide (Fe2O3) nanoparticles on the structure and function of the brain of rats. Electron microscopy showed Fe2O3 nanoparticles in the tissues of olfactory bulbs but not in the basal ganglia of the brain after their subchronic intranasal administration. We observed an increase in the number of axons with damaged myelin sheaths and in the proportion of pathologically altered mitochondria in the brains of the exposed animals against the background of almost stable blood parameters. We conclude that the central nervous system can be a target for toxicity of low-dose exposure to Fe2O3 nanoparticles. © 2023 by the authors.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85149053000
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000939322400001
U2 - 10.3390/ijms24043572
DO - 10.3390/ijms24043572
M3 - Article
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 4
M1 - 3572
ER -
ID: 35511491