The work describes an isotope generator of polonium-210 based on an extraction chromatographic resin SR Resin. It was shown that a high selectivity of 4,4’(5’)-di-t-butylcyclohexano-18-crown-6, an active component of SR Resin, for lead allows a clear separation of Pb-210 from impurities, easy elution of Po-210 with 5–7 mL of 0.05 M nitric acid solution as well as good retention of Pb-210 in the generator. The content of alpha emitting impurities in the Po-210 eluate did not exceed 0.65%. The experience of 3-years exploitation of the generator is described. It was shown that the SR Resin was stable against irradiation and complete drying, and Pb-210 loss from the SR Resin column for 3 years (seven elutions) was near to loss due to its radioactive decay within the error limits (less than 7%). © 2023 Elsevier Ltd