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Allentoft, M, Sikora, M, Refoyo-Martínez, A, Irving-Pease, EK, Fischer, A, Barrie, W, Ingason, A, Stenderup, J, Sjögren, K-G, Pearson, A, Sousa da Mota, B, Schulz Paulsson, B, Halgren, A, Macleod, R, Schjellerup Jørkov, ML, Demeter, F, Sørensen, L, Nielsen, PO, Henriksen, RA, Vimala, T, McColl, H, Margaryan, A, Ilardo, M, Vaughn, A, Mortensen, MF, Nielsen, AB, Ulfeldt Hede, M, Johannsen, N, Rasmussen, P, Vinner, L, Renaud, G, Stern, A, Trolle Jensen, TZ, Scorrano, G, Schroeder, H, Lysdahl, P, Ramsøe, AD, Skorobogatov, A, Schork, AJ, Rosengren, A, Ruter, A, Outram, A, Timoshenko, AA, Buzhilova, A, Coppa, A, Zubova, A, Silva, AM, Sablin, M, Hansen, A, Gromov, A, Logvin, A, Gotfredsen, AB, Nielsen, BH, González-Rabanal, B, Lalueza-Fox, C, McKenzie, CJ, Gaunitz, C, Blasco, C, Liesau, C, Martinez-Labarga, C, Pozdnyakov, D, Cuenca-Solana, D, Lordkipanidze, DO, Enshin, DN, Salazar-García, DC, Price, TD, Borić, D, Kostyleva, E, Veselovskaya, EV, Usmanova, ER, Cappellini, E, Brinch Petersen, E, Kannegaard, E, Radina, F, Eylem Yediay, F, Duday, H, Gutiérrez-Zugasti, I, Merts, I, Potekhina, I, Shevnina, I, Altinkaya, I, Guilaine, J, Hansen, J, Aura Tortosa, JE, Zilhão, J, Vega, J, Buck Pedersen, K, Tunia, K, Zhao, L, Mylnikova, LN, Larsson, L, Metz, L, Yepiskoposyan, L, Pedersen, L, Sarti, L, Orlando, L, Slimak, L, Klassen, L, Blank, M, González-Morales, M, Silvestrini, M, Vretemark, M, Nesterova, MS, Rykun, M, Rolfo, MF, Szmyt, M, Przybyła, M, Calattini, M, Dobisíková, M, Meldgaard, M, Johansen, M, Berezina, N, Card, N, Saveliev, NA, Poshekhonova, O, Rickards, O, Lozovskaya, OV, Gábor, O, Uldum, OC, Aurino, P, Courtaud, P, Patricia, R
, Kosintsev, P, Mortensen, P, Lotz, P, Persson, P, Bangsgaard, P, de Barros Damgaard, P, Petersen, PV, Martinez, PP, Włodarczak, P, Smolyaninov, RV, Maring, R, Menduiña, R, Badalyan, R, Iversen, R, Turin, R, Vasilyev, SV, Wåhlin, S, Borutskaya, S, Skochina, S, Sørensen, SA, Andersen, SH, Jørgensen, T, Serikov, YB, Molodin, VI, Smrcka, V, Merts, V, Appadurai, V, Moiseyev, V, Magnusson, Y, Kjær, KH, Lynnerup, N, Lawson, DJ, Sudmant, PH, Rasmussen, S, Korneliussen, TS, Durbin, R, Nielsen, R, Delaneau, O, Werge, T, Racimo, F, Kristiansen, K & Willerslev, E 2024, '
Population genomics of post-glacial western Eurasia',
Nature, vol. 625, no. 7994, pp. 301-311.
https://doi.org/10.1038/s41586-023-06865-0APA
Allentoft, M., Sikora, M., Refoyo-Martínez, A., Irving-Pease, E. K., Fischer, A., Barrie, W., Ingason, A., Stenderup, J., Sjögren, K-G., Pearson, A., Sousa da Mota, B., Schulz Paulsson, B., Halgren, A., Macleod, R., Schjellerup Jørkov, M. L., Demeter, F., Sørensen, L., Nielsen, P. O., Henriksen, R. A., ... Willerslev, E. (2024).
Population genomics of post-glacial western Eurasia.
Nature,
625(7994), 301-311.
https://doi.org/10.1038/s41586-023-06865-0Vancouver
Author
BibTeX
@article{d8329e01e55b4ad08d470b5781077019,
title = "Population genomics of post-glacial western Eurasia",
abstract = "Western Eurasia witnessed several large-scale human migrations during the Holocene1,2,3,4,5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a {\textquoteleft}great divide{\textquoteright} genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a {\textquoteleft}Neolithic steppe{\textquoteright} cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.",
author = "Morten Allentoft and Martin Sikora and Alba Refoyo-Mart{\'i}nez and Irving-Pease, {Evan K.} and Anders Fischer and William Barrie and Andr{\'e}s Ingason and Jesper Stenderup and Karl-G{\"o}ran Sj{\"o}gren and Alice Pearson and {Sousa da Mota}, B{\'a}rbara and {Schulz Paulsson}, Bettina and Alma Halgren and Ruairidh Macleod and {Schjellerup J{\o}rkov}, {Marie Louise} and Fabrice Demeter and Lasse S{\o}rensen and Nielsen, {Poul Otto} and Henriksen, {Rasmus A.} and Tharsika Vimala and Hugh McColl and Ashot Margaryan and Melissa Ilardo and Andrew Vaughn and Mortensen, {Morten Fischer} and Nielsen, {Anne Birgitte} and {Ulfeldt Hede}, Mikkel and Niels Johannsen and Peter Rasmussen and Lasse Vinner and Gabriel Renaud and Aaron Stern and {Trolle Jensen}, {Theis Zetner} and Gabriele Scorrano and Hannes Schroeder and Per Lysdahl and Rams{\o}e, {Abigail Daisy} and Andrei Skorobogatov and Schork, {Andrew Joseph} and Anders Rosengren and Anthony Ruter and Alan Outram and Timoshenko, {Aleksey A.} and Alexandra Buzhilova and Alfredo Coppa and Alisa Zubova and Silva, {Ana Maria} and Mikhail Sablin and Anders Hansen and Andrey Gromov and Andrey Logvin and Gotfredsen, {Anne Birgitte} and Nielsen, {Bjarne Henning} and Borja Gonz{\'a}lez-Rabanal and Carles Lalueza-Fox and McKenzie, {Catriona J.} and Charleen Gaunitz and Concepci{\'o}n Blasco and Corina Liesau and Cristina Martinez-Labarga and Dmitri Pozdnyakov and David Cuenca-Solana and Lordkipanidze, {David O.} and Enshin, {Dmitri N.} and Salazar-Garc{\'i}a, {Domingo C.} and Price, {T. Douglas} and Du{\v s}an Bori{\'c} and Elena Kostyleva and Veselovskaya, {Elizaveta V.} and Usmanova, {Emma R.} and Enrico Cappellini and {Brinch Petersen}, Erik and Esben Kannegaard and Francesca Radina and {Eylem Yediay}, Fulya and Henri Duday and Igor Guti{\'e}rrez-Zugasti and Ilya Merts and Inna Potekhina and Irina Shevnina and Isin Altinkaya and Jean Guilaine and Jesper Hansen and {Aura Tortosa}, {Joan Emili} and Jo{\~a}o Zilh{\~a}o and Jorge Vega and {Buck Pedersen}, Kristoffer and Krzysztof Tunia and Lei Zhao and Mylnikova, {Liudmila N.} and Lars Larsson and Laure Metz and Levon Yepiskoposyan and Lisbeth Pedersen and Lucia Sarti and Ludovic Orlando and Ludovic Slimak and Lutz Klassen and Malou Blank and Manuel Gonz{\'a}lez-Morales and Mara Silvestrini and Maria Vretemark and Nesterova, {Marina S.} and Marina Rykun and Rolfo, {Mario Federico} and Marzena Szmyt and Marcin Przyby{\l}a and Mauro Calattini and Milu{\v s}e Dobis{\'i}kov{\'a} and Morten Meldgaard and Morten Johansen and Natalia Berezina and Nick Card and Saveliev, {Nikolai A.} and Olga Poshekhonova and Olga Rickards and Lozovskaya, {Olga V.} and Oliv{\'e}r G{\'a}bor and Uldum, {Otto Christian} and Paola Aurino and Patrice Courtaud and R{\'i}os Patricia and Pavel Kosintsev and Peder Mortensen and Per Lotz and Per Persson and Pernille Bangsgaard and {de Barros Damgaard}, Peter and Petersen, {Peter Vang} and Martinez, {Pilar Prieto} and Piotr W{\l}odarczak and Smolyaninov, {Roman V.} and Rikke Maring and Roberto Mendui{\~n}a and Ruben Badalyan and Rune Iversen and Ruslan Turin and Vasilyev, {Sergey V.} and Sidsel W{\aa}hlin and Svetlana Borutskaya and Svetlana Skochina and S{\o}rensen, {S{\o}ren Anker} and Andersen, {S{\o}ren H.} and Thomas J{\o}rgensen and Serikov, {Yuri B.} and Molodin, {Vyacheslav I.} and Vaclav Smrcka and Victor Merts and Vivek Appadurai and Vyacheslav Moiseyev and Yvonne Magnusson and Kj{\ae}r, {Kurt H.} and Niels Lynnerup and Lawson, {Daniel J.} and Sudmant, {Peter H.} and Simon Rasmussen and Korneliussen, {Thorfinn Sand} and Richard Durbin and Rasmus Nielsen and Olivier Delaneau and Thomas Werge and Fernando Racimo and Kristian Kristiansen and Eske Willerslev",
note = "We acknowledge P. Bennike, who was involved in initiating this project, for her substantial contributions to its conception and to prehistoric research more broadly; she passed away in 2017. We thank L. Olsen and P. Selmer Olsen for administrative and technical assistance, respectively; the UK Biobank for access to the UK Biobank genomic resource; Illumina for collaboration; and S. Ellingv{\aa}g for assistance with sample access. E.W. thanks St John{\textquoteright}s College, Cambridge, for providing a stimulating environment of discussion and learning. The Lundbeck Foundation GeoGenetics Centre is supported by grants from the Lundbeck Foundation (R302-2018-2155 and R155-2013-16338), the Novo Nordisk Foundation (NNF18SA0035006), the Wellcome Trust (214300), the Carlsberg Foundation (CF18-0024), the Danish National Research Foundation (DNRF94, DNRF174), the University of Copenhagen (KU2016 programme) and Ferring Pharmaceuticals A/S to E.W. This research has been conducted using the UK Biobank Resource and the iPSYCH Initiative, funded by the Lundbeck Foundation (R102-A9118 and R155-2014-1724). This work was further supported by the Swedish Foundation for Humanities and Social Sciences grant (Riksbankens Jubileumsfond M16-0455:1) to K.K. M.E.A. was supported by Marie Sk{\l}odowska-Curie Actions of the EU (grant no. 300554), The Villum Foundation (grant no. 10120) and Independent Research Fund Denmark (grant no. 7027-00147B). W.B. is supported by the Hanne and Torkel Weis-Fogh Fund (Department of Zoology, University of Cambridge). A.P. is funded by the Wellcome grant WT214300; B.S.d.M and O.D. by the Swiss National Science Foundation (SFNS PP00P3_176977) and the European Research Council (ERC 679330);.",
year = "2024",
month = jan,
day = "11",
doi = "10.1038/s41586-023-06865-0",
language = "English",
volume = "625",
pages = "301--311",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7994",
}
RIS
TY - JOUR
T1 - Population genomics of post-glacial western Eurasia
AU - Allentoft, Morten
AU - Sikora, Martin
AU - Refoyo-Martínez, Alba
AU - Irving-Pease, Evan K.
AU - Fischer, Anders
AU - Barrie, William
AU - Ingason, Andrés
AU - Stenderup, Jesper
AU - Sjögren, Karl-Göran
AU - Pearson, Alice
AU - Sousa da Mota, Bárbara
AU - Schulz Paulsson, Bettina
AU - Halgren, Alma
AU - Macleod, Ruairidh
AU - Schjellerup Jørkov, Marie Louise
AU - Demeter, Fabrice
AU - Sørensen, Lasse
AU - Nielsen, Poul Otto
AU - Henriksen, Rasmus A.
AU - Vimala, Tharsika
AU - McColl, Hugh
AU - Margaryan, Ashot
AU - Ilardo, Melissa
AU - Vaughn, Andrew
AU - Mortensen, Morten Fischer
AU - Nielsen, Anne Birgitte
AU - Ulfeldt Hede, Mikkel
AU - Johannsen, Niels
AU - Rasmussen, Peter
AU - Vinner, Lasse
AU - Renaud, Gabriel
AU - Stern, Aaron
AU - Trolle Jensen, Theis Zetner
AU - Scorrano, Gabriele
AU - Schroeder, Hannes
AU - Lysdahl, Per
AU - Ramsøe, Abigail Daisy
AU - Skorobogatov, Andrei
AU - Schork, Andrew Joseph
AU - Rosengren, Anders
AU - Ruter, Anthony
AU - Outram, Alan
AU - Timoshenko, Aleksey A.
AU - Buzhilova, Alexandra
AU - Coppa, Alfredo
AU - Zubova, Alisa
AU - Silva, Ana Maria
AU - Sablin, Mikhail
AU - Hansen, Anders
AU - Gromov, Andrey
AU - Logvin, Andrey
AU - Gotfredsen, Anne Birgitte
AU - Nielsen, Bjarne Henning
AU - González-Rabanal, Borja
AU - Lalueza-Fox, Carles
AU - McKenzie, Catriona J.
AU - Gaunitz, Charleen
AU - Blasco, Concepción
AU - Liesau, Corina
AU - Martinez-Labarga, Cristina
AU - Pozdnyakov, Dmitri
AU - Cuenca-Solana, David
AU - Lordkipanidze, David O.
AU - Enshin, Dmitri N.
AU - Salazar-García, Domingo C.
AU - Price, T. Douglas
AU - Borić, Dušan
AU - Kostyleva, Elena
AU - Veselovskaya, Elizaveta V.
AU - Usmanova, Emma R.
AU - Cappellini, Enrico
AU - Brinch Petersen, Erik
AU - Kannegaard, Esben
AU - Radina, Francesca
AU - Eylem Yediay, Fulya
AU - Duday, Henri
AU - Gutiérrez-Zugasti, Igor
AU - Merts, Ilya
AU - Potekhina, Inna
AU - Shevnina, Irina
AU - Altinkaya, Isin
AU - Guilaine, Jean
AU - Hansen, Jesper
AU - Aura Tortosa, Joan Emili
AU - Zilhão, João
AU - Vega, Jorge
AU - Buck Pedersen, Kristoffer
AU - Tunia, Krzysztof
AU - Zhao, Lei
AU - Mylnikova, Liudmila N.
AU - Larsson, Lars
AU - Metz, Laure
AU - Yepiskoposyan, Levon
AU - Pedersen, Lisbeth
AU - Sarti, Lucia
AU - Orlando, Ludovic
AU - Slimak, Ludovic
AU - Klassen, Lutz
AU - Blank, Malou
AU - González-Morales, Manuel
AU - Silvestrini, Mara
AU - Vretemark, Maria
AU - Nesterova, Marina S.
AU - Rykun, Marina
AU - Rolfo, Mario Federico
AU - Szmyt, Marzena
AU - Przybyła, Marcin
AU - Calattini, Mauro
AU - Dobisíková, Miluše
AU - Meldgaard, Morten
AU - Johansen, Morten
AU - Berezina, Natalia
AU - Card, Nick
AU - Saveliev, Nikolai A.
AU - Poshekhonova, Olga
AU - Rickards, Olga
AU - Lozovskaya, Olga V.
AU - Gábor, Olivér
AU - Uldum, Otto Christian
AU - Aurino, Paola
AU - Courtaud, Patrice
AU - Patricia, Ríos
AU - Kosintsev, Pavel
AU - Mortensen, Peder
AU - Lotz, Per
AU - Persson, Per
AU - Bangsgaard, Pernille
AU - de Barros Damgaard, Peter
AU - Petersen, Peter Vang
AU - Martinez, Pilar Prieto
AU - Włodarczak, Piotr
AU - Smolyaninov, Roman V.
AU - Maring, Rikke
AU - Menduiña, Roberto
AU - Badalyan, Ruben
AU - Iversen, Rune
AU - Turin, Ruslan
AU - Vasilyev, Sergey V.
AU - Wåhlin, Sidsel
AU - Borutskaya, Svetlana
AU - Skochina, Svetlana
AU - Sørensen, Søren Anker
AU - Andersen, Søren H.
AU - Jørgensen, Thomas
AU - Serikov, Yuri B.
AU - Molodin, Vyacheslav I.
AU - Smrcka, Vaclav
AU - Merts, Victor
AU - Appadurai, Vivek
AU - Moiseyev, Vyacheslav
AU - Magnusson, Yvonne
AU - Kjær, Kurt H.
AU - Lynnerup, Niels
AU - Lawson, Daniel J.
AU - Sudmant, Peter H.
AU - Rasmussen, Simon
AU - Korneliussen, Thorfinn Sand
AU - Durbin, Richard
AU - Nielsen, Rasmus
AU - Delaneau, Olivier
AU - Werge, Thomas
AU - Racimo, Fernando
AU - Kristiansen, Kristian
AU - Willerslev, Eske
N1 - We acknowledge P. Bennike, who was involved in initiating this project, for her substantial contributions to its conception and to prehistoric research more broadly; she passed away in 2017. We thank L. Olsen and P. Selmer Olsen for administrative and technical assistance, respectively; the UK Biobank for access to the UK Biobank genomic resource; Illumina for collaboration; and S. Ellingvåg for assistance with sample access. E.W. thanks St John’s College, Cambridge, for providing a stimulating environment of discussion and learning. The Lundbeck Foundation GeoGenetics Centre is supported by grants from the Lundbeck Foundation (R302-2018-2155 and R155-2013-16338), the Novo Nordisk Foundation (NNF18SA0035006), the Wellcome Trust (214300), the Carlsberg Foundation (CF18-0024), the Danish National Research Foundation (DNRF94, DNRF174), the University of Copenhagen (KU2016 programme) and Ferring Pharmaceuticals A/S to E.W. This research has been conducted using the UK Biobank Resource and the iPSYCH Initiative, funded by the Lundbeck Foundation (R102-A9118 and R155-2014-1724). This work was further supported by the Swedish Foundation for Humanities and Social Sciences grant (Riksbankens Jubileumsfond M16-0455:1) to K.K. M.E.A. was supported by Marie Skłodowska-Curie Actions of the EU (grant no. 300554), The Villum Foundation (grant no. 10120) and Independent Research Fund Denmark (grant no. 7027-00147B). W.B. is supported by the Hanne and Torkel Weis-Fogh Fund (Department of Zoology, University of Cambridge). A.P. is funded by the Wellcome grant WT214300; B.S.d.M and O.D. by the Swiss National Science Foundation (SFNS PP00P3_176977) and the European Research Council (ERC 679330);.
PY - 2024/1/11
Y1 - 2024/1/11
N2 - Western Eurasia witnessed several large-scale human migrations during the Holocene1,2,3,4,5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
AB - Western Eurasia witnessed several large-scale human migrations during the Holocene1,2,3,4,5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85181851896
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001143579000017
U2 - 10.1038/s41586-023-06865-0
DO - 10.1038/s41586-023-06865-0
M3 - Article
VL - 625
SP - 301
EP - 311
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7994
ER -
