Standard

Population genomics of post-glacial western Eurasia. / Allentoft, Morten; Sikora, Martin; Refoyo-Martínez, Alba и др.
в: Nature, Том 625, № 7994, 11.01.2024, стр. 301-311.

Результаты исследований: Вклад в журналСтатьяРецензирование

Harvard

Allentoft, M, Sikora, M, Refoyo-Martínez, A, Irving-Pease, EK, Fischer, A, Barrie, W, Ingason, A, Stenderup, J, Sjögren, K-G, Pearson, A, Sousa da Mota, B, Schulz Paulsson, B, Halgren, A, Macleod, R, Schjellerup Jørkov, ML, Demeter, F, Sørensen, L, Nielsen, PO, Henriksen, RA, Vimala, T, McColl, H, Margaryan, A, Ilardo, M, Vaughn, A, Mortensen, MF, Nielsen, AB, Ulfeldt Hede, M, Johannsen, N, Rasmussen, P, Vinner, L, Renaud, G, Stern, A, Trolle Jensen, TZ, Scorrano, G, Schroeder, H, Lysdahl, P, Ramsøe, AD, Skorobogatov, A, Schork, AJ, Rosengren, A, Ruter, A, Outram, A, Timoshenko, AA, Buzhilova, A, Coppa, A, Zubova, A, Silva, AM, Sablin, M, Hansen, A, Gromov, A, Logvin, A, Gotfredsen, AB, Nielsen, BH, González-Rabanal, B, Lalueza-Fox, C, McKenzie, CJ, Gaunitz, C, Blasco, C, Liesau, C, Martinez-Labarga, C, Pozdnyakov, D, Cuenca-Solana, D, Lordkipanidze, DO, Enshin, DN, Salazar-García, DC, Price, TD, Borić, D, Kostyleva, E, Veselovskaya, EV, Usmanova, ER, Cappellini, E, Brinch Petersen, E, Kannegaard, E, Radina, F, Eylem Yediay, F, Duday, H, Gutiérrez-Zugasti, I, Merts, I, Potekhina, I, Shevnina, I, Altinkaya, I, Guilaine, J, Hansen, J, Aura Tortosa, JE, Zilhão, J, Vega, J, Buck Pedersen, K, Tunia, K, Zhao, L, Mylnikova, LN, Larsson, L, Metz, L, Yepiskoposyan, L, Pedersen, L, Sarti, L, Orlando, L, Slimak, L, Klassen, L, Blank, M, González-Morales, M, Silvestrini, M, Vretemark, M, Nesterova, MS, Rykun, M, Rolfo, MF, Szmyt, M, Przybyła, M, Calattini, M, Dobisíková, M, Meldgaard, M, Johansen, M, Berezina, N, Card, N, Saveliev, NA, Poshekhonova, O, Rickards, O, Lozovskaya, OV, Gábor, O, Uldum, OC, Aurino, P, Courtaud, P, Patricia, R, Kosintsev, P, Mortensen, P, Lotz, P, Persson, P, Bangsgaard, P, de Barros Damgaard, P, Petersen, PV, Martinez, PP, Włodarczak, P, Smolyaninov, RV, Maring, R, Menduiña, R, Badalyan, R, Iversen, R, Turin, R, Vasilyev, SV, Wåhlin, S, Borutskaya, S, Skochina, S, Sørensen, SA, Andersen, SH, Jørgensen, T, Serikov, YB, Molodin, VI, Smrcka, V, Merts, V, Appadurai, V, Moiseyev, V, Magnusson, Y, Kjær, KH, Lynnerup, N, Lawson, DJ, Sudmant, PH, Rasmussen, S, Korneliussen, TS, Durbin, R, Nielsen, R, Delaneau, O, Werge, T, Racimo, F, Kristiansen, K & Willerslev, E 2024, 'Population genomics of post-glacial western Eurasia', Nature, Том. 625, № 7994, стр. 301-311. https://doi.org/10.1038/s41586-023-06865-0

APA

Allentoft, M., Sikora, M., Refoyo-Martínez, A., Irving-Pease, E. K., Fischer, A., Barrie, W., Ingason, A., Stenderup, J., Sjögren, K-G., Pearson, A., Sousa da Mota, B., Schulz Paulsson, B., Halgren, A., Macleod, R., Schjellerup Jørkov, M. L., Demeter, F., Sørensen, L., Nielsen, P. O., Henriksen, R. A., ... Willerslev, E. (2024). Population genomics of post-glacial western Eurasia. Nature, 625(7994), 301-311. https://doi.org/10.1038/s41586-023-06865-0

Vancouver

Allentoft M, Sikora M, Refoyo-Martínez A, Irving-Pease EK, Fischer A, Barrie W и др. Population genomics of post-glacial western Eurasia. Nature. 2024 янв. 11;625(7994):301-311. doi: 10.1038/s41586-023-06865-0

Author

Allentoft, Morten ; Sikora, Martin ; Refoyo-Martínez, Alba и др. / Population genomics of post-glacial western Eurasia. в: Nature. 2024 ; Том 625, № 7994. стр. 301-311.

BibTeX

@article{d8329e01e55b4ad08d470b5781077019,
title = "Population genomics of post-glacial western Eurasia",
abstract = "Western Eurasia witnessed several large-scale human migrations during the Holocene1,2,3,4,5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a {\textquoteleft}great divide{\textquoteright} genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a {\textquoteleft}Neolithic steppe{\textquoteright} cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.",
author = "Morten Allentoft and Martin Sikora and Alba Refoyo-Mart{\'i}nez and Irving-Pease, {Evan K.} and Anders Fischer and William Barrie and Andr{\'e}s Ingason and Jesper Stenderup and Karl-G{\"o}ran Sj{\"o}gren and Alice Pearson and {Sousa da Mota}, B{\'a}rbara and {Schulz Paulsson}, Bettina and Alma Halgren and Ruairidh Macleod and {Schjellerup J{\o}rkov}, {Marie Louise} and Fabrice Demeter and Lasse S{\o}rensen and Nielsen, {Poul Otto} and Henriksen, {Rasmus A.} and Tharsika Vimala and Hugh McColl and Ashot Margaryan and Melissa Ilardo and Andrew Vaughn and Mortensen, {Morten Fischer} and Nielsen, {Anne Birgitte} and {Ulfeldt Hede}, Mikkel and Niels Johannsen and Peter Rasmussen and Lasse Vinner and Gabriel Renaud and Aaron Stern and {Trolle Jensen}, {Theis Zetner} and Gabriele Scorrano and Hannes Schroeder and Per Lysdahl and Rams{\o}e, {Abigail Daisy} and Andrei Skorobogatov and Schork, {Andrew Joseph} and Anders Rosengren and Anthony Ruter and Alan Outram and Timoshenko, {Aleksey A.} and Alexandra Buzhilova and Alfredo Coppa and Alisa Zubova and Silva, {Ana Maria} and Mikhail Sablin and Anders Hansen and Andrey Gromov and Andrey Logvin and Gotfredsen, {Anne Birgitte} and Nielsen, {Bjarne Henning} and Borja Gonz{\'a}lez-Rabanal and Carles Lalueza-Fox and McKenzie, {Catriona J.} and Charleen Gaunitz and Concepci{\'o}n Blasco and Corina Liesau and Cristina Martinez-Labarga and Dmitri Pozdnyakov and David Cuenca-Solana and Lordkipanidze, {David O.} and Enshin, {Dmitri N.} and Salazar-Garc{\'i}a, {Domingo C.} and Price, {T. Douglas} and Du{\v s}an Bori{\'c} and Elena Kostyleva and Veselovskaya, {Elizaveta V.} and Usmanova, {Emma R.} and Enrico Cappellini and {Brinch Petersen}, Erik and Esben Kannegaard and Francesca Radina and {Eylem Yediay}, Fulya and Henri Duday and Igor Guti{\'e}rrez-Zugasti and Ilya Merts and Inna Potekhina and Irina Shevnina and Isin Altinkaya and Jean Guilaine and Jesper Hansen and {Aura Tortosa}, {Joan Emili} and Jo{\~a}o Zilh{\~a}o and Jorge Vega and {Buck Pedersen}, Kristoffer and Krzysztof Tunia and Lei Zhao and Mylnikova, {Liudmila N.} and Lars Larsson and Laure Metz and Levon Yepiskoposyan and Lisbeth Pedersen and Lucia Sarti and Ludovic Orlando and Ludovic Slimak and Lutz Klassen and Malou Blank and Manuel Gonz{\'a}lez-Morales and Mara Silvestrini and Maria Vretemark and Nesterova, {Marina S.} and Marina Rykun and Rolfo, {Mario Federico} and Marzena Szmyt and Marcin Przyby{\l}a and Mauro Calattini and Milu{\v s}e Dobis{\'i}kov{\'a} and Morten Meldgaard and Morten Johansen and Natalia Berezina and Nick Card and Saveliev, {Nikolai A.} and Olga Poshekhonova and Olga Rickards and Lozovskaya, {Olga V.} and Oliv{\'e}r G{\'a}bor and Uldum, {Otto Christian} and Paola Aurino and Patrice Courtaud and R{\'i}os Patricia and Pavel Kosintsev and Peder Mortensen and Per Lotz and Per Persson and Pernille Bangsgaard and {de Barros Damgaard}, Peter and Petersen, {Peter Vang} and Martinez, {Pilar Prieto} and Piotr W{\l}odarczak and Smolyaninov, {Roman V.} and Rikke Maring and Roberto Mendui{\~n}a and Ruben Badalyan and Rune Iversen and Ruslan Turin and Vasilyev, {Sergey V.} and Sidsel W{\aa}hlin and Svetlana Borutskaya and Svetlana Skochina and S{\o}rensen, {S{\o}ren Anker} and Andersen, {S{\o}ren H.} and Thomas J{\o}rgensen and Serikov, {Yuri B.} and Molodin, {Vyacheslav I.} and Vaclav Smrcka and Victor Merts and Vivek Appadurai and Vyacheslav Moiseyev and Yvonne Magnusson and Kj{\ae}r, {Kurt H.} and Niels Lynnerup and Lawson, {Daniel J.} and Sudmant, {Peter H.} and Simon Rasmussen and Korneliussen, {Thorfinn Sand} and Richard Durbin and Rasmus Nielsen and Olivier Delaneau and Thomas Werge and Fernando Racimo and Kristian Kristiansen and Eske Willerslev",
note = "We acknowledge P. Bennike, who was involved in initiating this project, for her substantial contributions to its conception and to prehistoric research more broadly; she passed away in 2017. We thank L. Olsen and P. Selmer Olsen for administrative and technical assistance, respectively; the UK Biobank for access to the UK Biobank genomic resource; Illumina for collaboration; and S. Ellingv{\aa}g for assistance with sample access. E.W. thanks St John{\textquoteright}s College, Cambridge, for providing a stimulating environment of discussion and learning. The Lundbeck Foundation GeoGenetics Centre is supported by grants from the Lundbeck Foundation (R302-2018-2155 and R155-2013-16338), the Novo Nordisk Foundation (NNF18SA0035006), the Wellcome Trust (214300), the Carlsberg Foundation (CF18-0024), the Danish National Research Foundation (DNRF94, DNRF174), the University of Copenhagen (KU2016 programme) and Ferring Pharmaceuticals A/S to E.W. This research has been conducted using the UK Biobank Resource and the iPSYCH Initiative, funded by the Lundbeck Foundation (R102-A9118 and R155-2014-1724). This work was further supported by the Swedish Foundation for Humanities and Social Sciences grant (Riksbankens Jubileumsfond M16-0455:1) to K.K. M.E.A. was supported by Marie Sk{\l}odowska-Curie Actions of the EU (grant no. 300554), The Villum Foundation (grant no. 10120) and Independent Research Fund Denmark (grant no. 7027-00147B). W.B. is supported by the Hanne and Torkel Weis-Fogh Fund (Department of Zoology, University of Cambridge). A.P. is funded by the Wellcome grant WT214300; B.S.d.M and O.D. by the Swiss National Science Foundation (SFNS PP00P3_176977) and the European Research Council (ERC 679330);.",
year = "2024",
month = jan,
day = "11",
doi = "10.1038/s41586-023-06865-0",
language = "English",
volume = "625",
pages = "301--311",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7994",

}

RIS

TY - JOUR

T1 - Population genomics of post-glacial western Eurasia

AU - Allentoft, Morten

AU - Sikora, Martin

AU - Refoyo-Martínez, Alba

AU - Irving-Pease, Evan K.

AU - Fischer, Anders

AU - Barrie, William

AU - Ingason, Andrés

AU - Stenderup, Jesper

AU - Sjögren, Karl-Göran

AU - Pearson, Alice

AU - Sousa da Mota, Bárbara

AU - Schulz Paulsson, Bettina

AU - Halgren, Alma

AU - Macleod, Ruairidh

AU - Schjellerup Jørkov, Marie Louise

AU - Demeter, Fabrice

AU - Sørensen, Lasse

AU - Nielsen, Poul Otto

AU - Henriksen, Rasmus A.

AU - Vimala, Tharsika

AU - McColl, Hugh

AU - Margaryan, Ashot

AU - Ilardo, Melissa

AU - Vaughn, Andrew

AU - Mortensen, Morten Fischer

AU - Nielsen, Anne Birgitte

AU - Ulfeldt Hede, Mikkel

AU - Johannsen, Niels

AU - Rasmussen, Peter

AU - Vinner, Lasse

AU - Renaud, Gabriel

AU - Stern, Aaron

AU - Trolle Jensen, Theis Zetner

AU - Scorrano, Gabriele

AU - Schroeder, Hannes

AU - Lysdahl, Per

AU - Ramsøe, Abigail Daisy

AU - Skorobogatov, Andrei

AU - Schork, Andrew Joseph

AU - Rosengren, Anders

AU - Ruter, Anthony

AU - Outram, Alan

AU - Timoshenko, Aleksey A.

AU - Buzhilova, Alexandra

AU - Coppa, Alfredo

AU - Zubova, Alisa

AU - Silva, Ana Maria

AU - Sablin, Mikhail

AU - Hansen, Anders

AU - Gromov, Andrey

AU - Logvin, Andrey

AU - Gotfredsen, Anne Birgitte

AU - Nielsen, Bjarne Henning

AU - González-Rabanal, Borja

AU - Lalueza-Fox, Carles

AU - McKenzie, Catriona J.

AU - Gaunitz, Charleen

AU - Blasco, Concepción

AU - Liesau, Corina

AU - Martinez-Labarga, Cristina

AU - Pozdnyakov, Dmitri

AU - Cuenca-Solana, David

AU - Lordkipanidze, David O.

AU - Enshin, Dmitri N.

AU - Salazar-García, Domingo C.

AU - Price, T. Douglas

AU - Borić, Dušan

AU - Kostyleva, Elena

AU - Veselovskaya, Elizaveta V.

AU - Usmanova, Emma R.

AU - Cappellini, Enrico

AU - Brinch Petersen, Erik

AU - Kannegaard, Esben

AU - Radina, Francesca

AU - Eylem Yediay, Fulya

AU - Duday, Henri

AU - Gutiérrez-Zugasti, Igor

AU - Merts, Ilya

AU - Potekhina, Inna

AU - Shevnina, Irina

AU - Altinkaya, Isin

AU - Guilaine, Jean

AU - Hansen, Jesper

AU - Aura Tortosa, Joan Emili

AU - Zilhão, João

AU - Vega, Jorge

AU - Buck Pedersen, Kristoffer

AU - Tunia, Krzysztof

AU - Zhao, Lei

AU - Mylnikova, Liudmila N.

AU - Larsson, Lars

AU - Metz, Laure

AU - Yepiskoposyan, Levon

AU - Pedersen, Lisbeth

AU - Sarti, Lucia

AU - Orlando, Ludovic

AU - Slimak, Ludovic

AU - Klassen, Lutz

AU - Blank, Malou

AU - González-Morales, Manuel

AU - Silvestrini, Mara

AU - Vretemark, Maria

AU - Nesterova, Marina S.

AU - Rykun, Marina

AU - Rolfo, Mario Federico

AU - Szmyt, Marzena

AU - Przybyła, Marcin

AU - Calattini, Mauro

AU - Dobisíková, Miluše

AU - Meldgaard, Morten

AU - Johansen, Morten

AU - Berezina, Natalia

AU - Card, Nick

AU - Saveliev, Nikolai A.

AU - Poshekhonova, Olga

AU - Rickards, Olga

AU - Lozovskaya, Olga V.

AU - Gábor, Olivér

AU - Uldum, Otto Christian

AU - Aurino, Paola

AU - Courtaud, Patrice

AU - Patricia, Ríos

AU - Kosintsev, Pavel

AU - Mortensen, Peder

AU - Lotz, Per

AU - Persson, Per

AU - Bangsgaard, Pernille

AU - de Barros Damgaard, Peter

AU - Petersen, Peter Vang

AU - Martinez, Pilar Prieto

AU - Włodarczak, Piotr

AU - Smolyaninov, Roman V.

AU - Maring, Rikke

AU - Menduiña, Roberto

AU - Badalyan, Ruben

AU - Iversen, Rune

AU - Turin, Ruslan

AU - Vasilyev, Sergey V.

AU - Wåhlin, Sidsel

AU - Borutskaya, Svetlana

AU - Skochina, Svetlana

AU - Sørensen, Søren Anker

AU - Andersen, Søren H.

AU - Jørgensen, Thomas

AU - Serikov, Yuri B.

AU - Molodin, Vyacheslav I.

AU - Smrcka, Vaclav

AU - Merts, Victor

AU - Appadurai, Vivek

AU - Moiseyev, Vyacheslav

AU - Magnusson, Yvonne

AU - Kjær, Kurt H.

AU - Lynnerup, Niels

AU - Lawson, Daniel J.

AU - Sudmant, Peter H.

AU - Rasmussen, Simon

AU - Korneliussen, Thorfinn Sand

AU - Durbin, Richard

AU - Nielsen, Rasmus

AU - Delaneau, Olivier

AU - Werge, Thomas

AU - Racimo, Fernando

AU - Kristiansen, Kristian

AU - Willerslev, Eske

N1 - We acknowledge P. Bennike, who was involved in initiating this project, for her substantial contributions to its conception and to prehistoric research more broadly; she passed away in 2017. We thank L. Olsen and P. Selmer Olsen for administrative and technical assistance, respectively; the UK Biobank for access to the UK Biobank genomic resource; Illumina for collaboration; and S. Ellingvåg for assistance with sample access. E.W. thanks St John’s College, Cambridge, for providing a stimulating environment of discussion and learning. The Lundbeck Foundation GeoGenetics Centre is supported by grants from the Lundbeck Foundation (R302-2018-2155 and R155-2013-16338), the Novo Nordisk Foundation (NNF18SA0035006), the Wellcome Trust (214300), the Carlsberg Foundation (CF18-0024), the Danish National Research Foundation (DNRF94, DNRF174), the University of Copenhagen (KU2016 programme) and Ferring Pharmaceuticals A/S to E.W. This research has been conducted using the UK Biobank Resource and the iPSYCH Initiative, funded by the Lundbeck Foundation (R102-A9118 and R155-2014-1724). This work was further supported by the Swedish Foundation for Humanities and Social Sciences grant (Riksbankens Jubileumsfond M16-0455:1) to K.K. M.E.A. was supported by Marie Skłodowska-Curie Actions of the EU (grant no. 300554), The Villum Foundation (grant no. 10120) and Independent Research Fund Denmark (grant no. 7027-00147B). W.B. is supported by the Hanne and Torkel Weis-Fogh Fund (Department of Zoology, University of Cambridge). A.P. is funded by the Wellcome grant WT214300; B.S.d.M and O.D. by the Swiss National Science Foundation (SFNS PP00P3_176977) and the European Research Council (ERC 679330);.

PY - 2024/1/11

Y1 - 2024/1/11

N2 - Western Eurasia witnessed several large-scale human migrations during the Holocene1,2,3,4,5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.

AB - Western Eurasia witnessed several large-scale human migrations during the Holocene1,2,3,4,5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85181851896

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001143579000017

U2 - 10.1038/s41586-023-06865-0

DO - 10.1038/s41586-023-06865-0

M3 - Article

VL - 625

SP - 301

EP - 311

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7994

ER -

ID: 51598625