The article analyzes the experience of creation and development of the Department of History of Science and Technology at Ural Federal University. The article by the head of the Department of History of Science and Technology UGTU - UPI - UrFU Professor V.V. Zaparia and his colleagues from the department, docents V.A. Doroshenko and E.V. Zaytseva, analyze and summarize the almost 20-year history of the department. The article reveals the achievements of the department staff and its problematic moments, as well as considers the history and methods of teaching the main discipline of the department - the history of science and technology. The author describes the creation of methodological works in the form of textbooks, teaching aids and reading-books, multimedia courses. The authors not only summed up the results of the department, but also showed its place in the Russian school of historical research and analyzed the main directions of scientific work of the teaching staff.