An algorithm has been developed to evaluate how combinations of genetic polymorphisms affect the outcomes of pediatric ischemic strokes. Case series included 172 patients data base, all patients had MRI confirmation of stroke and signed concern form. Eight thrombophilic genes polymorphisms: FGB:-455G>A, F2:20210G>A, F5:1691G>A, F7:10976G>A, F13:103G>T, ITGA2:807C>T, ITGB3:1565T>C, PAI-1:-675 5G>4G, and four genes polymorphisms of folic acid enzymes: MTHFR:677C>T, MTHFR:1298A>C, MTRR:66A>G, MTR:2756A>G were established as feasible predictors. Combinations of genetic polymorphisms with nonzero values can have both effects: a destructive and a protective.