The research of autoclave ammonia leaching of silver from low-grade copper concentrates was conducted with the use of Zhezkazgan concentrates of the following composition, %: 9.55 Cu; Fe 4.84; S 5.6; 27.03 Si; 109.6 g/t Ag. According to x- ray phase analysis, the main minerals included in the concentrate are, %: 29 quartz (SiO2), 33 plagioclase ((Ca, Na)(Al, Si) AlSi2O6), 16 mica, 10 chalcosine (Cu2S), 2 chalcopyrite (CuFeS2), 7 pyrite (FeS2).It is shown that during the processing of ores in which gold and silver are in close association with sulfide minerals, pre- cious metals are not extracted by cyanidation even after operations of ultrafine grinding. The share of such persistent raw materials is more than 30% of the total ore reserves containing precious metals in the world. The application of the most common technologies of autoclaved sulphuric acid and neutral leaching for quantitative oxidation of containing gold and silver sulphides in this case is limited due to the formation of argentojarosite, inert relative to the cyanide ion. In order to avoid its formation and to increase the degree of leaching of silver directly at the autoclave stage, its extraction in am- monia media was investigated.32Direct autoclave leaching achieved copper recovery rates in 93-97%, while silver extraction was not observed in some experiments, which may be due to the sorption activity of aluminum and silicon compounds present in the concentrate. Preliminary mechanoactivation and surface renewal have a positive effect on the recovery rates of copper and silver in the solution. Additional operation of concentrate desillication allows to extract 97% copper and 83% silver in solution with the following options: [NH4OH] = 7 mol/dm, L:S = 10:1, τ = 3 h, pO = 0.6 MPa, t = 140 °С.