TY - JOUR

T1 - Towards experimental models of delirium utilizing zebrafish

AU - Maslov, Gleb O.

AU - Zabegalov, Konstantin N.

AU - Demin, Konstantin A.

AU - Kolesnikova, Tatiana O.

AU - Kositsyn, Yuriy M.

AU - Abreu, Murilo S.

AU - Petersen, Elena V.

AU - Kalueff, Allan V.

N1 - This study is supported by Sirius University of Science and Technology (Sochi, Russia). A.V.K. is supported by St. Petersburg State University . The study utilized the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684).

PY - 2023

Y1 - 2023

N2 - Delirium is an acute neuropsychiatric condition characterized by impaired behavior and cognition. Although the syndrome has been known for millennia, its CNS mechanisms and risk factors remain poorly understood. Experimental animal models, especially rodent-based, are commonly used to probe various pathogenetic aspects of delirium. Complementing rodents, the zebrafish (Danio rerio) emerges as a promising novel model organism to study delirium. Zebrafish demonstrate high genetic and physiological homology to mammals, easy maintenance, robust behaviors in various sensitive behavioral tests, and the potential to screen for pharmacological agents relevant to delirium. Here, we critically discuss recent developments in the field, and emphasize the developing utility of zebrafish models for translational studies of delirium and deliriant drugs. Overall, the zebrafish represents a valuable and promising aquatic model species whose use may help understand delirium etiology, as well as develop novel therapies for this severely debilitating disorder.

AB - Delirium is an acute neuropsychiatric condition characterized by impaired behavior and cognition. Although the syndrome has been known for millennia, its CNS mechanisms and risk factors remain poorly understood. Experimental animal models, especially rodent-based, are commonly used to probe various pathogenetic aspects of delirium. Complementing rodents, the zebrafish (Danio rerio) emerges as a promising novel model organism to study delirium. Zebrafish demonstrate high genetic and physiological homology to mammals, easy maintenance, robust behaviors in various sensitive behavioral tests, and the potential to screen for pharmacological agents relevant to delirium. Here, we critically discuss recent developments in the field, and emphasize the developing utility of zebrafish models for translational studies of delirium and deliriant drugs. Overall, the zebrafish represents a valuable and promising aquatic model species whose use may help understand delirium etiology, as well as develop novel therapies for this severely debilitating disorder.

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U2 - 10.1016/j.bbr.2023.114607

DO - 10.1016/j.bbr.2023.114607

M3 - Article

VL - 453

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 114607

ER -