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Synthesis and antinociceptive activity of nitriles, esters, and amides of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids. / Lipin, D.; Parkhoma, K. Y.; Shadrin, V. et al.
In:
Russian Chemical Bulletin, Vol. 72, No. 8, 2023, p. 1913-1920.
Research output: Contribution to journal › Article › peer-review
Harvard
Lipin, D, Parkhoma, KY, Shadrin, V, Makhmudov, R, Shipilovskikh, D
, Silaichev, P & Shipilovskikh, S 2023, '
Synthesis and antinociceptive activity of nitriles, esters, and amides of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids',
Russian Chemical Bulletin, vol. 72, no. 8, pp. 1913-1920.
https://doi.org/10.1007/s11172-023-3976-xAPA
Lipin, D., Parkhoma, K. Y., Shadrin, V., Makhmudov, R., Shipilovskikh, D.
, Silaichev, P., & Shipilovskikh, S. (2023).
Synthesis and antinociceptive activity of nitriles, esters, and amides of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids.
Russian Chemical Bulletin,
72(8), 1913-1920.
https://doi.org/10.1007/s11172-023-3976-xVancouver
Lipin D, Parkhoma KY, Shadrin V, Makhmudov R, Shipilovskikh D
, Silaichev P et al.
Synthesis and antinociceptive activity of nitriles, esters, and amides of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids.
Russian Chemical Bulletin. 2023;72(8):1913-1920. doi: 10.1007/s11172-023-3976-x
Author
Lipin, D. ; Parkhoma, K. Y. ; Shadrin, V. et al. /
Synthesis and antinociceptive activity of nitriles, esters, and amides of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids. In:
Russian Chemical Bulletin. 2023 ; Vol. 72, No. 8. pp. 1913-1920.
BibTeX
@article{f486057731764617941ae849bb3b6568,
title = "Synthesis and antinociceptive activity of nitriles, esters, and amides of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids",
abstract = "Synthesis of nitriles, esters, amides of the substituted 2-amino-1-(4,5,6,7-tetra-hydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids bearing the nitrile group at the thiophene ring by the reaction of the substituted 3-(3-cyanothiophen-2-yl)iminofuran-2(3H)-ones with the appropriate cyanoacetic acid derivatives was developed. The synthesized compounds demonstrated pronounced antinociceptive activity and low toxicity (toxicity class V of practically nontoxic substances). {\textcopyright} 2023, Springer Science+Business Media LLC.",
author = "D. Lipin and Parkhoma, {K. Y.} and V. Shadrin and R. Makhmudov and D. Shipilovskikh and P. Silaichev and S. Shipilovskikh",
note = "This study was performed under financial support of the “Rational Use of the Earth Interior” Perm Scientific Educational Center 2023.",
year = "2023",
doi = "10.1007/s11172-023-3976-x",
language = "English",
volume = "72",
pages = "1913--1920",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer",
number = "8",
}
RIS
TY - JOUR
T1 - Synthesis and antinociceptive activity of nitriles, esters, and amides of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids
AU - Lipin, D.
AU - Parkhoma, K. Y.
AU - Shadrin, V.
AU - Makhmudov, R.
AU - Shipilovskikh, D.
AU - Silaichev, P.
AU - Shipilovskikh, S.
N1 - This study was performed under financial support of the “Rational Use of the Earth Interior” Perm Scientific Educational Center 2023.
PY - 2023
Y1 - 2023
N2 - Synthesis of nitriles, esters, amides of the substituted 2-amino-1-(4,5,6,7-tetra-hydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids bearing the nitrile group at the thiophene ring by the reaction of the substituted 3-(3-cyanothiophen-2-yl)iminofuran-2(3H)-ones with the appropriate cyanoacetic acid derivatives was developed. The synthesized compounds demonstrated pronounced antinociceptive activity and low toxicity (toxicity class V of practically nontoxic substances). © 2023, Springer Science+Business Media LLC.
AB - Synthesis of nitriles, esters, amides of the substituted 2-amino-1-(4,5,6,7-tetra-hydrobenzo[b]thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylic acids bearing the nitrile group at the thiophene ring by the reaction of the substituted 3-(3-cyanothiophen-2-yl)iminofuran-2(3H)-ones with the appropriate cyanoacetic acid derivatives was developed. The synthesized compounds demonstrated pronounced antinociceptive activity and low toxicity (toxicity class V of practically nontoxic substances). © 2023, Springer Science+Business Media LLC.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85169683408
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001062790500023
U2 - 10.1007/s11172-023-3976-x
DO - 10.1007/s11172-023-3976-x
M3 - Article
VL - 72
SP - 1913
EP - 1920
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 8
ER -
