For a city to turn into a smart city, suitable framework conditions have to enable and enhance the required creativity of the inhabitants. If new technologies are meant to establish fast connections between citizens, also in order to strengthen channels for innovative activities, then smart institutions should operate under framework conditions, which integrate the employees to allow an optimal functioning of these institutions with respect to the societal goals of a smart city. This chapter introduces a concept and an indicator of smart institutions, focusing on research-oriented public institutions. These concepts are discussed by means of case studies involving institutions providing maximum medical supply and access to high-performance medicine. Framework conditions, raising the degree ofsmartness, are analyzed as well. Some remarks on smart government and smart institutions in other sectors of the economy are included as well.