Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity
AU - Nosova, Emiliya
AU - Lipunova, Galina
AU - Permyakova, Yulia
AU - Charushin, Valery
N1 - Funding from Ministry of Science and Higher Education of the Russian Federation, project FEUZ-2023-0021\u00BB.
PY - 2024/5/1
Y1 - 2024/5/1
N2 - This review covers article and patent data obtained mostly within the period 2013–2023 on the synthesis and biological activity of quinazolines [c]-annelated by five- and six-membered heterocycles. Pyrazolo-, benzimidazo-, triazolo- and pyrimido- [c]quinazoline systems have shown multiple potential activities against numerous targets. We highlight that most research efforts are directed to design of anticancer and antibacterial agents of azolo[c]quinazoline nature. This review emphases both on the medicinal chemistry aspects of pyrrolo[c]-, azolo[c]- and azino[c]quinazolines and comprehensive synthetic strategies of quinazolines annelated at N(3)–C(4) bond in the perspective of drug development and discovery.
AB - This review covers article and patent data obtained mostly within the period 2013–2023 on the synthesis and biological activity of quinazolines [c]-annelated by five- and six-membered heterocycles. Pyrazolo-, benzimidazo-, triazolo- and pyrimido- [c]quinazoline systems have shown multiple potential activities against numerous targets. We highlight that most research efforts are directed to design of anticancer and antibacterial agents of azolo[c]quinazoline nature. This review emphases both on the medicinal chemistry aspects of pyrrolo[c]-, azolo[c]- and azino[c]quinazolines and comprehensive synthetic strategies of quinazolines annelated at N(3)–C(4) bond in the perspective of drug development and discovery.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85191153669
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001233485300001
U2 - 10.1016/j.ejmech.2024.116411
DO - 10.1016/j.ejmech.2024.116411
M3 - Article
VL - 271
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
SN - 0223-5234
M1 - 116411
ER -
ID: 56642868