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Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action. / Sharapov, Ainur D.; Fatykhov, Ramil F.; Khalymbadzha, Igor A. et al.
In: International Journal of Molecular Sciences, Vol. 24, No. 3, 2839, 01.2023.

Research output: Contribution to journal › Review article › peer-review

Harvard

Sharapov, AD, Fatykhov, RF, Khalymbadzha, IA, Zyryanov, GV, Chupakhin, ON & Tsurkan, MV 2023, 'Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action', International Journal of Molecular Sciences, vol. 24, no. 3, 2839. https://doi.org/10.3390/ijms24032839

APA

Sharapov, A. D., Fatykhov, R. F., Khalymbadzha, I. A., Zyryanov, G. V., Chupakhin, O. N., & Tsurkan, M. V. (2023). Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action. International Journal of Molecular Sciences, 24(3), [2839]. https://doi.org/10.3390/ijms24032839

Vancouver

Sharapov AD, Fatykhov RF, Khalymbadzha IA, Zyryanov GV, Chupakhin ON, Tsurkan MV. Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action. International Journal of Molecular Sciences. 2023 Jan;24(3):2839. doi: 10.3390/ijms24032839

Author

Sharapov, Ainur D. ; Fatykhov, Ramil F. ; Khalymbadzha, Igor A. et al. / Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 3.

BibTeX

@article{2443837d62f74881961cea92c5f16fec,
title = "Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action",
abstract = "This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action. This review summarizes the information on the anti-HIV properties of simple coumarins as well as annulated furano- and pyranocoumarins and shows that coumarins of plant origin can act by several mechanisms: inhibition of HIV reverse transcriptase and integrase, inhibition of cellular factors that regulate HIV-1 replication, and transmission of viral particles from infected macrophages to healthy ones. It is important to note that some pyranocoumarins are able to act through several mechanisms or bind to several sites, which ensures the resistance of these compounds to HIV mutations. Here we review the last two decades of research on the anti-HIV activity of naturally occurring coumarins.",
author = "Sharapov, {Ainur D.} and Fatykhov, {Ramil F.} and Khalymbadzha, {Igor A.} and Zyryanov, {Grigory V.} and Chupakhin, {Oleg N.} and Tsurkan, {Mikhail V.}",
note = "This research was funded by the Ministry of Science and Higher Education of the Russian Federation grant 075-15-2022-1118 (Section “Simple coumarins”) and the Russian Science Foundation, grant number 21-13-00382 (Sections “Furocoumarins” and “Pyranocoumarins”).",
year = "2023",
month = jan,
doi = "10.3390/ijms24032839",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action

AU - Sharapov, Ainur D.

AU - Fatykhov, Ramil F.

AU - Khalymbadzha, Igor A.

AU - Zyryanov, Grigory V.

AU - Chupakhin, Oleg N.

AU - Tsurkan, Mikhail V.

N1 - This research was funded by the Ministry of Science and Higher Education of the Russian Federation grant 075-15-2022-1118 (Section “Simple coumarins”) and the Russian Science Foundation, grant number 21-13-00382 (Sections “Furocoumarins” and “Pyranocoumarins”).

PY - 2023/1

Y1 - 2023/1

N2 - This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action. This review summarizes the information on the anti-HIV properties of simple coumarins as well as annulated furano- and pyranocoumarins and shows that coumarins of plant origin can act by several mechanisms: inhibition of HIV reverse transcriptase and integrase, inhibition of cellular factors that regulate HIV-1 replication, and transmission of viral particles from infected macrophages to healthy ones. It is important to note that some pyranocoumarins are able to act through several mechanisms or bind to several sites, which ensures the resistance of these compounds to HIV mutations. Here we review the last two decades of research on the anti-HIV activity of naturally occurring coumarins.

AB - This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action. This review summarizes the information on the anti-HIV properties of simple coumarins as well as annulated furano- and pyranocoumarins and shows that coumarins of plant origin can act by several mechanisms: inhibition of HIV reverse transcriptase and integrase, inhibition of cellular factors that regulate HIV-1 replication, and transmission of viral particles from infected macrophages to healthy ones. It is important to note that some pyranocoumarins are able to act through several mechanisms or bind to several sites, which ensures the resistance of these compounds to HIV mutations. Here we review the last two decades of research on the anti-HIV activity of naturally occurring coumarins.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85147895066

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000932571000001

U2 - 10.3390/ijms24032839

DO - 10.3390/ijms24032839

M3 - Review article

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 3

M1 - 2839

ER -

ID: 34717683