Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Modeling Tauopathies in Zebrafish (Danio rerio)
AU - Kotova, М.
AU - Kolesnikova, Т. о.
AU - Kalueff, A.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of the tau protein in the brain, which causes clinical dementia. The tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, it aggregates in the brain. Tauopaties can be divided into primary and secondary (e.g., Alzheimer’s disease). Experimental animal models are an important tool to study tauopathies. Here, we discuss molecular mechanisms of tauopathies and their available experimental models in both rodents and a relatively novel model organism, the zebrafish (Danio rerio), as well as outline novel research trends in this field.
AB - Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of the tau protein in the brain, which causes clinical dementia. The tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, it aggregates in the brain. Tauopaties can be divided into primary and secondary (e.g., Alzheimer’s disease). Experimental animal models are an important tool to study tauopathies. Here, we discuss molecular mechanisms of tauopathies and their available experimental models in both rodents and a relatively novel model organism, the zebrafish (Danio rerio), as well as outline novel research trends in this field.
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001137643100013
UR - https://elibrary.ru/item.asp?id=64700545
U2 - 10.1134/S0022093023060133
DO - 10.1134/S0022093023060133
M3 - Review article
VL - 59
SP - 2055
EP - 2071
JO - Journal of Evolutionary Biochemistry and Physiology
JF - Journal of Evolutionary Biochemistry and Physiology
SN - 0022-0930
IS - 6
ER -
ID: 53854968