Using the sol-gel and coprecipitation methods, individual oxides of silicon, titanium, zirconium and double oxides TiO2–SiO2, TiO2–ZrO2, ZrO2–SiO2 have been synthesized. Modification with carboxylic acids was carried out at the final stage of synthesis before drying. Their adsorption and acid-base properties, which allowed establish a number of key parameters that determine the texture and features of the hydrate-hydroxyl structure of the samples, were studied in the range pK = 1.3–11.6. It was shown that the formation of a molecular imprint of aromatic carboxylic acids in composites during their sol-gel synthesis is an efficient approach for creating catalysts for the asymmetric Biginelli reaction.