The article is devoted to the global factors affecting the workers' well-being in the context of the work prosses transformation under the Industry 4.0. The study is aimed at examination the problem of the negative impact of economy globalization and digitalization on the socio-psychological employees’ well-being. As a research method, a sociological survey conducted by the authors was used, in which 800 people living in six regions of the Russian Federation participated. The index method was used for a correct comparison of the obtained quantitative indicators. A subjective respondent's assessment of different aspects of professional activities is took as an indicator for calculating the employee's socio-psychological well-being index. The survey results were processed using cluster analysis as an effective method of working with fuzzy information. It has been established workers groups at risk, who demonstrate low rates of socio-psychological well-being and a high level of concern about global socio-economic risks.