TY - JOUR

T1 - Impact of Magneto-Deformation Effect in Ferrogels on the Echogenicity of Magnetic Composites

AU - Dinislamova, Olga A.

AU - Yaryshev, Ilya O.

AU - Bugayova, Antonina V.

AU - Shklyar, Tatyana F.

AU - Safronov, Alexander P.

AU - Lotfollahi, Zahra

AU - Blyakhman, Felix A.

N1 - The study was supported by the program of the Ministry of Health of the Russian Federation (project 121032300335-1). A. P. Safronov thanks the Russian Science Foundation (Grant No. 20-12-00031) for ¯nancial support in the synthesis and characterization of FGs. We thank D. V. Kuznetsova and I. Orue for special support. Selected studies were made at SGIKER Common Services of UPV-EHU.

PY - 2023

Y1 - 2023

N2 - Basically, this study was carried out in the context of the development of ferrogel-based biocompatible soft tissue implants, in particular, for the needs of regenerative medicine and replacement therapy. The magneto-deformation e®ect (MDE) of ferrogels (FGs) and the possibility of its visualization with the use of medical ultrasound were in the focus of this work. The aim of this investigation was addressed to search a possible relationship between the extent of MDE and the intensity of the re°ected echo signal at the gel/water interface and in the gel interior. Cylindrical FGs ~ 12 mm in diameter and ~ 7 mm in height based on polyacrylamide (PAAm) with interpenetrating physical network of natural polysaccharide (Guar) ¯lled with 200–300 nm Fe3O4 magnetic microparticles (MPs) with weight fraction of 12% or 23% were investigated. MDE was studied using an ultrasonic medical device Sonoline Adara (Siemens, Germany), and estimated by the relative compression of FGs after application the constant gradient magnetic ¯eld (MF) up to 500 Oe by an electromagnet. Viscoelastic and acoustic properties of FGs in the absence of the application of an MF were determined as well. It was found that an increase of the weight fraction of MPs in FGs resulted in the signi¯cant increase of the ferrogel's density, the elastic storage modulus, the loss modulus, the acoustic impedance, the re°ection coe±cient and some decrease of the ultrasonic velocity in FGs. At a given MPs concentration, the MDE in FGs was increased according to a quadratic law with the gradual increase of MF strength. The growth of MDE in FGs accompanies by an increase in the intensity of the re°ected echo signal both from the gel/water interface and from the interior of the FGs. The obtained results are discussed from the viewpoint of the e®ects of MPs on the interaction of an ultrasonic wave with the structure of FGs in the course of MF application. © World Scienti¯c Publishing Company.

AB - Basically, this study was carried out in the context of the development of ferrogel-based biocompatible soft tissue implants, in particular, for the needs of regenerative medicine and replacement therapy. The magneto-deformation e®ect (MDE) of ferrogels (FGs) and the possibility of its visualization with the use of medical ultrasound were in the focus of this work. The aim of this investigation was addressed to search a possible relationship between the extent of MDE and the intensity of the re°ected echo signal at the gel/water interface and in the gel interior. Cylindrical FGs ~ 12 mm in diameter and ~ 7 mm in height based on polyacrylamide (PAAm) with interpenetrating physical network of natural polysaccharide (Guar) ¯lled with 200–300 nm Fe3O4 magnetic microparticles (MPs) with weight fraction of 12% or 23% were investigated. MDE was studied using an ultrasonic medical device Sonoline Adara (Siemens, Germany), and estimated by the relative compression of FGs after application the constant gradient magnetic ¯eld (MF) up to 500 Oe by an electromagnet. Viscoelastic and acoustic properties of FGs in the absence of the application of an MF were determined as well. It was found that an increase of the weight fraction of MPs in FGs resulted in the signi¯cant increase of the ferrogel's density, the elastic storage modulus, the loss modulus, the acoustic impedance, the re°ection coe±cient and some decrease of the ultrasonic velocity in FGs. At a given MPs concentration, the MDE in FGs was increased according to a quadratic law with the gradual increase of MF strength. The growth of MDE in FGs accompanies by an increase in the intensity of the re°ected echo signal both from the gel/water interface and from the interior of the FGs. The obtained results are discussed from the viewpoint of the e®ects of MPs on the interaction of an ultrasonic wave with the structure of FGs in the course of MF application. © World Scienti¯c Publishing Company.

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U2 - 10.1142/S2010324723400027

DO - 10.1142/S2010324723400027

M3 - Article

VL - 13

JO - SPIN

JF - SPIN

SN - 2010-3247

IS - 02

M1 - 2340002

ER -