Effective pickering emulsifiers based on submicron carboxymethyl cellulose/chitosan polymer particles

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Effective pickering emulsifiers based on submicron carboxymethyl cellulose/chitosan polymer particles. / Mensah, Emmanuel o.; Alqubelat, Rita; Menzorova, Yaroslava A. et al.
In: Colloids and Surfaces B: Biointerfaces, Vol. 236, 113827, 01.04.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{3e500882f4cf493684a7ea3a0c68aac5,

title = "Effective pickering emulsifiers based on submicron carboxymethyl cellulose/chitosan polymer particles",

abstract = "In this study, cross-linked carboxymethyl cellulose/chitosan submicron particles were employed to facilitate the stabilization of Pickering emulsion. The polymer particles were prepared using the polyelectrolyte self-assembly method in conjunction with isocyanide based multicomponent reactions and the characteristics were obtained using: nuclear magnetic resonance, Fourier-transform infrared spectroscopy and dynamic light scattering. Atomic force microscopy revealed the heterogeneous structure of the resulting submicron particles with domains of 20–30 nm in size. The average diameter was found to be in the range of 229–378 nm and they were found to be suitable for the fabrication of oil/water Pickering emulsion when proceeded via the homogenization method followed by sonication. The results obtained revealed that carboxymethyl cellulose/chitosan particles significantly stabilized the droplets at the oil/water interface. Even at low particle concentrations of 0.3 g/L (which is close to that of low molecular weight surfactants) stable Pickering emulsions have been obtained. Additionally, the resulting emulsions showed a high level of stability with regard to changes in pH, temperature and ionic strength. The natural alkaloid piperine was used as a model compound to load the resulting particles, which possessed encapsulation efficiency of 90.6±0.4%. Furthermore, the in vitro release profile of piperine from the Pickering emulsion revealed a much-controlled release in both acidic and neutral media as compared to the unformulated piperine. Additional findings in this work revealed important information on the application of carboxymethyl cellulose/chitosan submicron particles as Pickering stabilizers for creation of new delivery systems.",

author = "Mensah, {Emmanuel o.} and Rita Alqubelat and Menzorova, {Yaroslava A.} and Artem Minin and Maxim Mironov",

note = "Authors thank Russian Science Foundation for financial support Grant 23–23–00125",

year = "2024",

month = apr,

day = "1",

doi = "10.1016/j.colsurfb.2024.113827",

language = "English",

volume = "236",

journal = "Colloids and Surfaces B: Biointerfaces",

issn = "0927-7765",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Effective pickering emulsifiers based on submicron carboxymethyl cellulose/chitosan polymer particles

AU - Mensah, Emmanuel o.

AU - Alqubelat, Rita

AU - Menzorova, Yaroslava A.

AU - Minin, Artem

AU - Mironov, Maxim

N1 - Authors thank Russian Science Foundation for financial support Grant 23–23–00125

PY - 2024/4/1

Y1 - 2024/4/1

N2 - In this study, cross-linked carboxymethyl cellulose/chitosan submicron particles were employed to facilitate the stabilization of Pickering emulsion. The polymer particles were prepared using the polyelectrolyte self-assembly method in conjunction with isocyanide based multicomponent reactions and the characteristics were obtained using: nuclear magnetic resonance, Fourier-transform infrared spectroscopy and dynamic light scattering. Atomic force microscopy revealed the heterogeneous structure of the resulting submicron particles with domains of 20–30 nm in size. The average diameter was found to be in the range of 229–378 nm and they were found to be suitable for the fabrication of oil/water Pickering emulsion when proceeded via the homogenization method followed by sonication. The results obtained revealed that carboxymethyl cellulose/chitosan particles significantly stabilized the droplets at the oil/water interface. Even at low particle concentrations of 0.3 g/L (which is close to that of low molecular weight surfactants) stable Pickering emulsions have been obtained. Additionally, the resulting emulsions showed a high level of stability with regard to changes in pH, temperature and ionic strength. The natural alkaloid piperine was used as a model compound to load the resulting particles, which possessed encapsulation efficiency of 90.6±0.4%. Furthermore, the in vitro release profile of piperine from the Pickering emulsion revealed a much-controlled release in both acidic and neutral media as compared to the unformulated piperine. Additional findings in this work revealed important information on the application of carboxymethyl cellulose/chitosan submicron particles as Pickering stabilizers for creation of new delivery systems.

AB - In this study, cross-linked carboxymethyl cellulose/chitosan submicron particles were employed to facilitate the stabilization of Pickering emulsion. The polymer particles were prepared using the polyelectrolyte self-assembly method in conjunction with isocyanide based multicomponent reactions and the characteristics were obtained using: nuclear magnetic resonance, Fourier-transform infrared spectroscopy and dynamic light scattering. Atomic force microscopy revealed the heterogeneous structure of the resulting submicron particles with domains of 20–30 nm in size. The average diameter was found to be in the range of 229–378 nm and they were found to be suitable for the fabrication of oil/water Pickering emulsion when proceeded via the homogenization method followed by sonication. The results obtained revealed that carboxymethyl cellulose/chitosan particles significantly stabilized the droplets at the oil/water interface. Even at low particle concentrations of 0.3 g/L (which is close to that of low molecular weight surfactants) stable Pickering emulsions have been obtained. Additionally, the resulting emulsions showed a high level of stability with regard to changes in pH, temperature and ionic strength. The natural alkaloid piperine was used as a model compound to load the resulting particles, which possessed encapsulation efficiency of 90.6±0.4%. Furthermore, the in vitro release profile of piperine from the Pickering emulsion revealed a much-controlled release in both acidic and neutral media as compared to the unformulated piperine. Additional findings in this work revealed important information on the application of carboxymethyl cellulose/chitosan submicron particles as Pickering stabilizers for creation of new delivery systems.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85186522912

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001203870600001

U2 - 10.1016/j.colsurfb.2024.113827

DO - 10.1016/j.colsurfb.2024.113827

M3 - Article

VL - 236

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

M1 - 113827

ER -

ID: 53803702