Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models
AU - Ilyin, Nikita P.
AU - Petersen, Elena V.
AU - Kolesnikova, Tatyana
AU - Demin, Konstantin A.
AU - Khatsko, Sergey l.
AU - Apuhtin, Kirill V.
AU - Kalueff, Allan
N1 - The work was financially supported by the St. Petersburg State University budgetary funds (Project ID 94030626). A.V.K. and T.O.K. are supported by the Sirius University of Science and Technology budgetary funds (Project ID NRB-RND-2116).
PY - 2024/2/1
Y1 - 2024/2/1
N2 - High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience. These fish share some practical advantages over mammalian models together with high genetic homology and evolutionarily conserved biochemical and neurobehavioral phenotypes, thus enabling large-scale modeling of human brain diseases. Here, we review mounting evidence on peripheral biomarkers of brain disorders in zebrafish models, focusing on altered biochemistry (lipids, carbohydrates, proteins, and other non-signal molecules, as well as metabolic reactions and activity of enzymes). Collectively, these data strongly support the utility of zebrafish (from a systems biology standpoint) to study peripheral manifestations of brain disorders, as well as highlight potential applications of biochemical biomarkers in zebrafish models to biomarker-based drug discovery and development.
AB - High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience. These fish share some practical advantages over mammalian models together with high genetic homology and evolutionarily conserved biochemical and neurobehavioral phenotypes, thus enabling large-scale modeling of human brain diseases. Here, we review mounting evidence on peripheral biomarkers of brain disorders in zebrafish models, focusing on altered biochemistry (lipids, carbohydrates, proteins, and other non-signal molecules, as well as metabolic reactions and activity of enzymes). Collectively, these data strongly support the utility of zebrafish (from a systems biology standpoint) to study peripheral manifestations of brain disorders, as well as highlight potential applications of biochemical biomarkers in zebrafish models to biomarker-based drug discovery and development.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85188257183
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001190797800010
U2 - 10.1134/S0006297924020160
DO - 10.1134/S0006297924020160
M3 - Review article
VL - 89
SP - 377
EP - 391
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
SN - 0006-2979
IS - 2
ER -
ID: 55295685