COMPARATIVE ANALYSIS OF THE BIOLOGICAL PROPERTIES OF ETHANOL EXTRACTS OF THE GENUS MONARDA REPRESENTATIVES ON THE EXAMPLE OF DROSOPHILA MELANOGASTER

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COMPARATIVE ANALYSIS OF THE BIOLOGICAL PROPERTIES OF ETHANOL EXTRACTS OF THE GENUS MONARDA REPRESENTATIVES ON THE EXAMPLE OF DROSOPHILA MELANOGASTER. / Antosyuk, Olga; Bolotnik, Elizaveta; Sakova, Irina.
In: Indian Drugs, Vol. 60, No. 11, 2023, p. 43-50.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{0889b9930fd6468599295605d0bb8589,

title = "COMPARATIVE ANALYSIS OF THE BIOLOGICAL PROPERTIES OF ETHANOL EXTRACTS OF THE GENUS MONARDA REPRESENTATIVES ON THE EXAMPLE OF DROSOPHILA MELANOGASTER",

abstract = "Determination of toxic, genotoxic and cytotoxic effects of Drosophila melanogaster for Monarda fistulosa var. menthifolia, M. fistulosa, M. didyma and M. media was carried out. The Oregon-R line was used to test for toxic manifestations in a number of indicators: fecundity, early and late embryonic mortality of offspring and total lethality of individuals (LC50). The genotoxic effect was recorded using SMART. The change in the wing shape and regulated cell death was determined. The lethality of individuals grown on a nutrient medium with the addition of an extract of M. fistulosa var. menthifolia, as well as F1 offspring at the embryonic stage of development was studied. Genotoxicity was not registered for any of the tested extracts. The M. didyma extract is characterized by cytotoxic properties. An effect on viability was found for extracts of M. media and M. fistulosa var. menthifolia. Cytotoxic effect was observed when exposed to M. didyma extract. {\textcopyright} 2023 Indian Drug Manufacturers' Association. All rights reserved.",

author = "Olga Antosyuk and Elizaveta Bolotnik and Irina Sakova",

note = "The authors are grateful to Marvin N.A. for maintaining lines from the Drosophila collection, Pavlova O.S. for comments, Paukov A.G. for moral support. The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged.",

year = "2023",

doi = "10.53879/id.60.11.13711",

language = "English",

volume = "60",

pages = "43--50",

journal = "Indian Drugs",

issn = "0019-462X",

publisher = "Indian Drug Manufacturers' Association",

number = "11",

}

RIS

TY - JOUR

T1 - COMPARATIVE ANALYSIS OF THE BIOLOGICAL PROPERTIES OF ETHANOL EXTRACTS OF THE GENUS MONARDA REPRESENTATIVES ON THE EXAMPLE OF DROSOPHILA MELANOGASTER

AU - Antosyuk, Olga

AU - Bolotnik, Elizaveta

AU - Sakova, Irina

N1 - The authors are grateful to Marvin N.A. for maintaining lines from the Drosophila collection, Pavlova O.S. for comments, Paukov A.G. for moral support. The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged.

PY - 2023

Y1 - 2023

N2 - Determination of toxic, genotoxic and cytotoxic effects of Drosophila melanogaster for Monarda fistulosa var. menthifolia, M. fistulosa, M. didyma and M. media was carried out. The Oregon-R line was used to test for toxic manifestations in a number of indicators: fecundity, early and late embryonic mortality of offspring and total lethality of individuals (LC50). The genotoxic effect was recorded using SMART. The change in the wing shape and regulated cell death was determined. The lethality of individuals grown on a nutrient medium with the addition of an extract of M. fistulosa var. menthifolia, as well as F1 offspring at the embryonic stage of development was studied. Genotoxicity was not registered for any of the tested extracts. The M. didyma extract is characterized by cytotoxic properties. An effect on viability was found for extracts of M. media and M. fistulosa var. menthifolia. Cytotoxic effect was observed when exposed to M. didyma extract. © 2023 Indian Drug Manufacturers' Association. All rights reserved.

AB - Determination of toxic, genotoxic and cytotoxic effects of Drosophila melanogaster for Monarda fistulosa var. menthifolia, M. fistulosa, M. didyma and M. media was carried out. The Oregon-R line was used to test for toxic manifestations in a number of indicators: fecundity, early and late embryonic mortality of offspring and total lethality of individuals (LC50). The genotoxic effect was recorded using SMART. The change in the wing shape and regulated cell death was determined. The lethality of individuals grown on a nutrient medium with the addition of an extract of M. fistulosa var. menthifolia, as well as F1 offspring at the embryonic stage of development was studied. Genotoxicity was not registered for any of the tested extracts. The M. didyma extract is characterized by cytotoxic properties. An effect on viability was found for extracts of M. media and M. fistulosa var. menthifolia. Cytotoxic effect was observed when exposed to M. didyma extract. © 2023 Indian Drug Manufacturers' Association. All rights reserved.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85182381662

U2 - 10.53879/id.60.11.13711

DO - 10.53879/id.60.11.13711

M3 - Article

VL - 60

SP - 43

EP - 50

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 11

ER -

ID: 51663234