The unique analytic potential of biofluids crystallooptic diagnostics (COD) is determined by visualization of aggregation properties and molecular biofluid organization, that reflect an important information about functional state of separate systems as well as about the physiological status of the whole organism (crystalloinformation). Extraction, visualization and processing of the diagnostic information are supplied by the smart-technology. COD techniques experience in studies of bile, urine, liquor, tear, saliva, blood and other biological fluids is generalized: Crystallooptic diagnosticums are the pool of analytical system "Mesotest". Combining of biofluids COD with the modern computer technologies transfer such methods into the category of intellectual prompts.