Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Behavioral profile of adult zebrafish acutely exposed to a selective dopamine uptake inhibitor, GBR 12909
AU - Zabegalov, Konstantin
AU - Costa, Fabiano
AU - Viktorova, Yuliya
AU - Maslov, Gleb
AU - Kolesnikova, Tatiana
AU - Gerasimova, Elena
AU - Grinevich, Vladimir
AU - Budygin, Evgeny
AU - Kalueff, Allan
N1 - The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research was supported by the Sirius University of Science and Technology projects NRB-RND-2116 (KNZ, FC, TOK, EVG, AVK) and NRB-RND-2114 (YAV, VPG, EAB). GOM summer internship at Sirius University of Science and Technology and his project contribution were supported by Ural Federal University. AVK research was supported by St. Petersburg State University (Project No 93020614).
PY - 2023/6/1
Y1 - 2023/6/1
N2 - Background: The dopamine transporter (DAT) is the main regulator of dopamine concentration in the extrasynaptic space. The pharmacological inhibition of the DAT results in a wide spectrum of behavioral manifestations, which have been identified so far in a limited number of species, mostly in rodents. Aim: Here, we used another well-recognized model organism, the zebrafish (Danio rerio), to explore the behavioral effects of GBR 12909, a highly-affine selective DAT blocker. Methods: We evaluated zebrafish locomotion, novelty-related exploration, spatial cognition, and social phenotypes in the novel tank, habituation and shoaling tests, following acute 20-min water immersion in GBR 12909. Results: Our findings show hypolocomotion, anxiety-like state, and impaired spatial cognition in fish acutely treated with GBR 12909. This behavioral profile generally parallels that of the DAT knockout rodents and zebrafish, and it overlaps with behavioral effects of other DAT-inhibiting drugs of abuse, such as cocaine and D-amphetamine. Conclusion: Collectively, our data support the utility of zebrafish in translational studies on DAT targeting neuropharmacology and strongly implicate DAT aberration as an important mechanisms involved in neurological and psychiatric diseases.
AB - Background: The dopamine transporter (DAT) is the main regulator of dopamine concentration in the extrasynaptic space. The pharmacological inhibition of the DAT results in a wide spectrum of behavioral manifestations, which have been identified so far in a limited number of species, mostly in rodents. Aim: Here, we used another well-recognized model organism, the zebrafish (Danio rerio), to explore the behavioral effects of GBR 12909, a highly-affine selective DAT blocker. Methods: We evaluated zebrafish locomotion, novelty-related exploration, spatial cognition, and social phenotypes in the novel tank, habituation and shoaling tests, following acute 20-min water immersion in GBR 12909. Results: Our findings show hypolocomotion, anxiety-like state, and impaired spatial cognition in fish acutely treated with GBR 12909. This behavioral profile generally parallels that of the DAT knockout rodents and zebrafish, and it overlaps with behavioral effects of other DAT-inhibiting drugs of abuse, such as cocaine and D-amphetamine. Conclusion: Collectively, our data support the utility of zebrafish in translational studies on DAT targeting neuropharmacology and strongly implicate DAT aberration as an important mechanisms involved in neurological and psychiatric diseases.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85153765954
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000976888000001
U2 - 10.1177/02698811231166463
DO - 10.1177/02698811231166463
M3 - Article
VL - 37
SP - 601
EP - 609
JO - Journal of Psychopharmacology
JF - Journal of Psychopharmacology
SN - 0269-8811
IS - 6
ER -
ID: 41535454