The 6-aryl-3-(6-methoxycarbonylpyridin-2-yl)-1,2,4-triaizines were synthesized by condensation of arylsubstituted 2-bromoacetophenones with methyl 6-(hydrazinocarbonyl)picolinate in DMF in one step with yields up to 70%. In case of using the mixture of ethanol and glacial acetic acid the similar reaction with 2-bromo-4'methylthioacetophenone results in the only product - bis[(6-methoxycarbonylpyridin-2-yl)carbonyl]hydrazone of (4-methylthiophenyl)glyoxal.