There was made the research of radiation-induced adaptation for the yeast culture of the strain Saccharomyces serevisiae. Yeast culture was contained in a nutrient medium and a cell's counting was carried out by using a Goryaev camera. The radiation-induced adaptation was observed the increasing of half-lethal doses for cells that was adapted by using a 10 cGy dose. It was found there is a radiation-induced adaptive response that manifested in an increase in the half-lethal dose. The increasing is observed by acute irradiation in the dose range of 2-12 kGy for cells that were previously irradiated with an adaptive dose of 10cGy. It is shown that the change in radioresistant cells observed in the time interval between adapting and acute exposures 2 and 4 weeks. The adaptive response is not preserved for an 8-week interval.