The article deals with social and political views and activities of the Ural regional head of healthcare Ivan S. Belostotsky, who became the first chief of the Yekaterinburg Healthcare Department after the restoration of the Soviet power in the Urals in summer 1919 and then the chief of the Regional Healthcare Department of the Ural Region since 1923. The article also gives an assessment of Belostotsky’s activities, shows his first attempts at reforming the healthcare system at the regional level and draws conclusions about the direct link between his pre-revolutionary party experience and development of his administrative career. Belostotsky’s participation in overcoming the epidemic morbidity in the region and developing draft plans for hospital and resort construction in the Urals is specially studied. The article provides information about his fate in the 1920s and 1930s when he managed to avoid criminal responsibility despite common accusations of that time in Trotskyism and sabotage.