Relevance of the research topic. Evaluation of changes in the index characteristics of oral hygiene, physicochemical parameters of mixed saliva (pH, buffer capacity of saliva, redox potential, osmolality and others) allows to determine the quality of the effect of toothpaste «Рarodontax ultra clean» on the state of the oral cavity. The use of mixed saliva as a biological fluid of the body as an object of study is confirmed by its high information content and availability of diagnostic material. Studies of changes in mixed saliva, whose components affect the composition, accumulation of microbial plaque and the process of its calcification are appropriate. Purpose. То evaluate the clinical efficacy of toothpaste «Рarodontax ultra clean», the complex effect of its components on the tissues of the teeth and of fabric of parоdontium, to determine the possible mechanism of anti-inflammatory action. Materials and methods. The experiment involved 58 people. The clinical examination included: Green-Vermillion hygiene indices; bleeding, gingivitis, parоdontium indices. Laboratory studies of unstimulated mixed saliva included parameters: qualitative analysis of the secret, a number of physico-chemical parameters; crystallographic characteristics. For an integrated assessment of nonspecific resistance of the oral cavity, the reaction of adsorption of microorganisms by epithelial cells was used. Results. In the course of use by patients of toothpaste «Рarodontax ultra clean», an improvement in the oral hygiene condition was noted, a decrease in the rate of plaque formation was diagnosed in 100% of cases, which is clinically confirmed by positive dynamics of hygiene indices (p < 0.05). With regular use of toothpaste, the inflammation of the gums decreases: after 7 days the bleeding of the gums decreases twice, after 14 days - 4.5 times. Summary. The use of toothpaste «Рarodontax ultra clean» leads to a qualitative transformation of the structure of mixed saliva in patients: an improvement in microcrystallization, an increase in salivation, an increase in pH values and bringing it into the range of normal values, an increase in buffer capacity and osmolality. Ingredients such as sodium bicarbonate, silicon dioxide and sodium fluoride contribute to the improvement of metabolic processes in the oral cavity and the adsorption properties of the epithelium after exposure to the investigated toothpaste.