Subject. The subject of this research is the dental health status and related diabetes mellitus and osteoporosis. Objective. The objective of this research is to determine specific characteristics of defeat teeth and periodontal tissues, as well the clinical course of periodontitis in elderly patients with diabetes mellitus and osteoporosis. Methodology. In a clinical examination of elderly women (aged 55-65) with periodontal inflammation and during their follow-ups at the stage of supporting therapy, three groups were formed (each with 20 subjects). The first group consisted of patients with Type II diabetes mellitus and osteoporosis; the second group consisted of osteoporotic patients; the third (reference) group consisted of patients who were the same age and considered themselves practically healthy at case control studies with follow-ups and periodontal inflammation in remission. Results and discussion. DMFT index was 19.6 ± 2.35 for the patients in the first group, 1.31 times lower for the patients in the second group and 1.38 times lower for the patients in the third group. Russel’s periodontal index was 3.5 ± 0.8 in the first group, 1.46 times lower in the second group and 1.84 lower in the third group. Conclusion. The research found the direct correlation between defeat teeth and more aggressive periodontitis in the patients with Type II diabetes mellitus and osteoporosis. Specific characteristics of defeat teeth are determined by higher Green-Vermillion oral hygiene indices, higher caries intensity with specific prevalence of “D” in both DMFT and DMFS indices. Increasing saliva viscosity decreases patient adaptation and adversely impacts on the organs of the oral cavity in the group of women with Type II diabetes mellitus and osteoporosis.