Titanium alloy VTI-4 based on orthorhombic titanium aluminide Ti2AlNb is studied in the initial condition and after charging with hydrogen to different concentrations. The kinetics and the rate of hydrogen release from the hydrogen-charged alloys during 30-min hold at 900°C in a flow of a high-purity inert gas (argon) is analyzed. The curves obtained by differential scanning calorimetry and thermal gravimetric analysis are plotted under continuous heating to 1200°C in the inert argon atmosphere at a rate of 20 °C/min. The microstructure of the alloy is studied.