In the course of the study, the analysis of the effectiveness of pedagogical technologies in preparation for the Unified State Exam in Chemistry was carried out: pre-university training courses at the Medical University; profile school; non-core school. Three pedagogical approaches with appropriate technologies were presented. The systematic approach in synergetic methodology is characterized by the traditional way of teaching. This is the use of lectures, practical exercises and independent work with the proposed literature. System-modular technology within the framework of an integrated approach is that the content of training is presented in modules that concisely represent information. An integrative approach to teaching, thanks to the author's training programs, allows you to move from individual knowledge and skills in the subject of chemistry to a complex synthesis of interdisciplinary knowledge and access to the Olympiad level of training for senior students. On the basis of the studied pedagogical approaches, it was concluded that there is no need to consider preparation for passing the exam in chemistry as a carefully thought-out pedagogical process. The methodological experience of many years of work of teachers and lecturers is sublimated into educational technology. It is based on a consistent presentation of the material in accordance with the Federal State Educational Standard of secondary (complete) education, taking into account the individual characteristics of technology subjects in a rigid connection with the formation of natural science literacy and independence of students. This is achieved as a result of the gradual accumulation and sequential complication of the theoretical and practical content of the studied material, the implementation of an individual approach to work with a student planning to take the USE. The effectiveness of pedagogical technology is manifested in the maximum degree of student involvement in this activity, as well as a high level of independence in working out the material.