There is a great interest of physicians, biologists and biophysicists to microwave radiometry using methods of passive radar. Because it is a bloodless, painless, rapid and harmless measuring method of temperatures of the internal areas of the human body based on its own thermal radiation in the microwave range. Receiving information is performed by the antenna-applicators that are installed on the surface of the human body. Radiothermograph detects electromagnetic radiation that is proportional to brightness temperature, is associated with the physical temperature of tissues and the absorption degree of electromagnetic waves in them. There were simulated vibratory, and spiral resonator-slot antenna-applicators to select the type of antenna applicator for microwave antenna array. Calculations of characteristics of coordination and absorption of the electromagnetic field in the near zone were made. Research of the antenna-applicators and developed receiving module are the basis for the creation of a modern multi-channel medical radiothermograph. Features of microwave radiothermograph for functional studies of the brain are shown. A block diagram of biotechnical systems with multichannel radiophysical complex are presented. The prospects of application of microwave radiometry methods in mammology, gynecology, and urology. The research results about creation of devices for the diagnosis of pathological changes in human organism using the methods of microwave radiometry confirm the prospects of work in this direction based on a new element base with using achievements of nano - and microelectronics and modern information technologies.