The paper deals with economic security problems in network conjugate productions. A methodology for studying the economic security of network conjugate productions is proposed including synergistic, reproductive and institutional approaches. The implementation of the fourth industrial revolution under the conditions of network-centricity of the industry markets is analyzed. The 4.0 Industry threats are identified. It is concluded that to increase the economic security effectiveness in network conjugate productions a comprehensive assessment of external and internal threats is required as well as the assessment of macroeconomic indices.