The scientific article is devoted to the study of factors of influence of operational management on the project activity of a large industrial company in the context of maintaining a competitive position. Investment activity of large industrial companies is one of the main activities, carrying out significant capital investments, subjects of economic relations increase production volumes, enter new markets. The subject of the research is economic relations arising in the process of influence of operational management on the project activities of a large industrial company. The paper considers investment activity from the point of view of operational management and evaluation of economic feasibility of projects. The relationship between project and operational activities is aimed at the formation of business needs and as a result to maintain the current position in the long and medium term development of a large industrial company. The paper also considers the negative impact of operational management on project activities, which can be divided into two types: within the framework of its responsibilities as one of the stakeholders and beyond the prescribed functionality. The main scientific results of this study include the determination of the impact of management decisions on the results of the project on the terms on which they are taken, which allows to determine the negative impact of operational management within the functional responsibilities and beyond. In conclusion, conclusions and recommendations are made to the TOP management of a large industrial company to minimize the negative impact of operational management on project activities.