The monograph contains the results of research concerning, firstly, the ecosystem as a response to the challenges of the XXI century. Secondly, the problems of labor longevity and success in organizations that form an ecosystem approach to working with personnel, including through the use in practice of biomedical factors, socio-economic conditions, nagging as a "soft power" to push older workers to productive work. Thirdly, the realities and problems of combining work and private life, studied from several positions. Among them: the formation of corporate policy, corporate interest, professional orientation; the actual balance of "work — private life", as well as the optimization of labor behavior through the formation of a sense of self-esteem in the workplace, the management of employees ' experience. Fourth, systematization of the results of the health management study, taking into account the experience gained during the coronavirus pandemic — occupational safety management, health promotion in the organization, including the situation of self-isolation. Fifth, the concept of compliance in the personnel management system.For students, undergraduates, postgraduates, doctoral students, researchers studying or conducting research in the field of personnel management, as well as the teaching staff of universities and employers.