In this article, the necessity of integrated approach to the analysis and solution of problems of safety of water supply and wastewater treatment are declared. The results of the study the main problems of the systems of production of water supply and wastewater treatment are described. Practical measures for solving problems are proposed. Pressing need of application of means of informatization, strategic risk analysis methods and innovative technologies of water treatment are declared. The basic principles of safe and effective critical systems of water supply and wastewater treatment in the sphere of production are proposed.