Contradictory trends of the national economy development characterize as well industrial regions' development, including «Great Urals». The latter is composed of regions of the Russian Federation with leading positions in the given macro-region and of regions - «outsiders» according to the growth of industrial production index, financial results, volume of investments in fixed assets, real disposable incomes of population and other indicators. The assessment of the Sverdlovsk region's economy - the largest industrial region of the country - allows to conclude that the gap in labour productivity in the industry of the region more than three times in comparison with foreign countries' indicators is one of the most important factors of low competitiveness of separate branches of industry. Overcoming the negative trends in the Sverdlovsk region, as well as in Russia as a whole requires a change in the strategic direction of development, its focusing at the implementation of a new industrialization. In the Middle Urals the necessary human capital, creativity and core competencies are already forming. The applying of them in the utilization of available mineral, scientific, technological, industrial and institutional resources will make it possible to adjust the strategic vector of the regional economy development in accordance with the global trends of technological development. The authors revealed the possibilities of using space for the economic growth as one of the most important resources of new industrialization. The paper contains the results of utilization of the methodological works for the elaboration of «The Program of the modernization and the creation of new jobs in the territory of Sverdlovsk region for the period till 2020».