The research is aimed at identifying the main problems in the financing of research in the high-tech sector of the economy of Kazakhstan in the implementation of the state priority policy of national science. The aim of the research was to find out why the reforms of the long-term state policy for the development of national science did not lead to an increase in research funding and the role of science in the national innovation system and to propose mechanisms of public-private partnership to solve the identified problems. The results obtained in the course of the study are of practical interest to the authorized bodies of the state science and innovation policy of Kazakhstan, subjects of innovation infrastructure and entrepreneurs in the field of science and innovation. The recommendations are designed to adjust the innovation policy of Kazakhstan, in terms of attracting additional financial resources in the implementation of research projects developed at universities and research institutes of the country. The article is prepared on the basis of original data obtained by the results of an independent expert survey of scientists with experience in management and implementation of research projects on the basis of state and other types of funding and co-financing. According to the results of the survey, the trend of dissatisfaction of scientists with the existing system of financing of science is clearly traced, as well as the presence of their own opinions about specific measures to solve the existing problems in this area. Based on the analysis of international experience in the application of the main forms of public-private partnership in the field of science and innovation, priority measures to enhance the participation of institutional investors in the long-term financing of high-tech projects are proposed