US-Israeli relations have been one of the key factors defining Middle East regional policy for a few decades. The relations between the USA and Israel to a large extent depend on personality of the American President and his party line. The article addresses political actions of the 45th US Republican President Donald Trump towards Israel, their impact on US-Israeli relations, Middle East regional situation and public moods in the two countries. Purpose of the study is to carry out an analysis of foreign policy activity of Donald Trump towards Israel, its results and tendencies of evolution of US-Israeli relations in 2016-2020. Materials and methods. As a part of the study, the authors examined news resources, analytical articles of Russian and foreign authors, statistical data and official websites of state and international organizations. The key methods of the study are analytical and comparative. Results, discussion. Basing on the results of the research, it can be concluded that Donald Trump’s Middle East policy has a pro-Israeli bias, what results in strengthening of the relations between the USA and Israel and increase of the American President’s approval rate in Israeli society. On the other hand, some actions of the US President contradict international law and UN resolutions, what negatively affects President Trump’s image both on the international arena and in American society, destabilizes Middle East regional situation and does not promote achievement of positive results in frames of Arab-Israeli conflict.