The article reveals the possibilities of using econometric models in forecasting the level of economic security of the inter-branch complex. Formulation of the definition of the concept of “interindustry complex”, a review of the main methods of econometric modeling and forecasting the dynamics of regional industrial markets are presented in the article. The main components of economic security in the inter-branch complex, analysis of the impact of the components of economic security on the integral indicator are identified. The methodology of forecasting the structural and space-time dynamics of interindustry complexes is considered, including new and refined methods of modeling and forecasting. The definitions of the terms “interindustry complex”, “economic security in the inter-branch complex of the Russian Federation” are proposed. General provisions of the methodology of econometric modeling and forecasting of the level of economic security of the inter-branch complex of the Russian Federation are proposed. It is shown that the level of economic safety of individual industries can be affected by the change in the network chain. The degree of network conjugate productions influence on the construction industry is calculated